Tbio USP45 Ubiquitin carboxyl-terminal hydrolase 45

Protein Summary

Description

The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q70EL2
• B2RXG0
• Q5T062
• Q86T44
• Q86TC0
• Q9BRU1

Gene Name

• USP45

Ensembl ID

• ENST00000327681
• ENSP00000333376
• ENSG00000123552
• ENST00000500704
• ENSP00000424372

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.93
protein domain	0.73
transcription factor perturbation	0.68
microRNA	0.66
molecular function	0.6

Protein Classes

PANTHER Classes

Protein / ... / Cysteine Protease / Ubiquitin Carboxyl-terminal Hydrolase 45

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Ubiquitin Carboxyl-terminal Hydrolase 45

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.6   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.6   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0