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Tbio
USP39
U4/U6.U5 tri-snRNP-associated protein 2

Protein Summary
Description
Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity (PubMed:18728397).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323701
  • ENSP00000312981
  • ENSG00000168883
  • ENST00000409470
  • ENSP00000386864
  • ENST00000409766
  • ENSP00000386803
  • ENST00000450066
  • ENSP00000396133

Symbol
  • 65K
  • SAD1
  • CGI-21
  • HSPC332
  • SNRNP65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
disease perturbation
0.9
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.57   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.57   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0