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Tbio
USP38
Ubiquitin carboxyl-terminal hydrolase 38

Protein Summary
Description
Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked ubiquitin chains.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307017
  • ENSP00000303434
  • ENSG00000170185
  • ENST00000510377
  • ENSP00000427647

Symbol
  • KIAA1891
  • HP43.8KD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
microRNA
0.65
cell line
0.63
tissue sample
0.59
histone modification site profile
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.73   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.73   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
HIST1H1D
Tbio
Novelty:  0.00922175
p_int:  0.998944055
p_ni:  0.001055945
Score:  0.228
Data Source:  BioPlex,STRINGDB
AHSG
Tbio
Novelty:  0.00112502
p_int:  0.997691439
p_ni:  0.002308561
Score:  0.534
Data Source:  BioPlex,STRINGDB
ADAR
Tbio
Family:  Enzyme
Novelty:  0.00135586
p_int:  0.947782036
p_ni:  0.052217964
Score:  0.68
Data Source:  BioPlex,STRINGDB
WDR48
Tbio
Novelty:  0.04070481
Score:  0.81
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.732
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.728
Data Source:  STRINGDB
INPP4A
Tbio
Family:  Enzyme
Novelty:  0.03714963
Score:  0.652
Data Source:  STRINGDB
USP54
Tdark
Family:  Enzyme
Novelty:  0.31344498
Score:  0.645
Data Source:  STRINGDB
PAN2
Tbio
Family:  Enzyme
Novelty:  0.1195117
Score:  0.638
Data Source:  STRINGDB
NEK1
Tchem
Family:  Kinase
Novelty:  0.0164923
Score:  0.601
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (45)
Find Similar Targets
Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Integrated Breast Cancer Pathway
WikiPathways
Integrated Breast Cancer Pathway
WikiPathways
Integrated Breast Cancer Pathway
WikiPathways
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WikiPathways
Alzheimers Disease
Name
Explore in Pharos
Explore in Source
Integrated Breast Cancer Pathway
Integrated Breast Cancer Pathway
Integrated Breast Cancer Pathway
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
Alzheimers Disease
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
3
4
89.1
urate measurement
2
2
2
77.7
antisocial behaviour measurement
1
1
1
64.4
1
1
1
64.4
substance abuse
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
89.1
urate measurement
2
77.7
antisocial behaviour measurement
1
64.4
1
64.4
substance abuse
1
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 38
VGNC:713
461515
Macaque
ubiquitin specific peptidase 38
700235
Mouse
MGI:1922091
74841
Rat
RGD:1311974
307764
Dog
ubiquitin specific peptidase 38
VGNC:48193
476071
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 38
Macaque
ubiquitin specific peptidase 38
Mouse
Rat
Dog
ubiquitin specific peptidase 38
Publication Statistics
PubMed Score 32.73
PubMed score by year
PubTator Score 2.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title