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Tbio
USP37
Ubiquitin carboxyl-terminal hydrolase 37

Protein Summary
Description
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258399
  • ENSP00000258399
  • ENSG00000135913
  • ENST00000415516
  • ENSP00000400902
  • ENST00000418019
  • ENSP00000396585
  • ENST00000454775
  • ENSP00000393662

Symbol
  • KIAA1594
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
virus perturbation
0.76
microRNA
0.73
transcription factor
0.68
transcription factor binding site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.9   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.9   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999999612
p_ni:  8.5e-8
p_wrong:  3.03e-7
Score:  0.473
Data Source:  BioPlex,STRINGDB
FZR1
Tbio
Novelty:  0.01599606
p_int:  0.999993944
p_ni:  4.46e-7
p_wrong:  0.000005609
Score:  0.423
Data Source:  BioPlex,STRINGDB
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.998235926
p_ni:  0.000002118
p_wrong:  0.001761956
Score:  0.621
Data Source:  BioPlex,STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
Score:  0.953
Data Source:  Reactome,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
Score:  0.914
Data Source:  Reactome,STRINGDB
CCNA1
Tbio
Novelty:  0.0065671
Score:  0.903
Data Source:  Reactome,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
Score:  0.902
Data Source:  Reactome,STRINGDB
WDR73
Tbio
Novelty:  0.10253438
Score:  0.715
Data Source:  STRINGDB
CDT1
Tbio
Novelty:  0.00398013
Score:  0.669
Data Source:  STRINGDB
MED13
Tbio
Family:  Enzyme
Novelty:  0.02090708
Score:  0.668
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deubiquitination (R-HSA-5688426)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
92.7
reticulocyte count
2
2
2
90.4
body height
3
3
3
88.6
sex hormone-binding globulin measurement
4
2
4
80.7
hemoglobin measurement
1
1
1
80
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
92.7
reticulocyte count
2
90.4
body height
3
88.6
sex hormone-binding globulin measurement
4
80.7
hemoglobin measurement
1
80
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 37
VGNC:3870
459944
Macaque
ubiquitin specific peptidase 37
701732
Mouse
MGI:2442483
319651
Rat
RGD:2319715
100361658
Dog
ubiquitin specific peptidase 37
VGNC:48192
488523
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 37
Macaque
ubiquitin specific peptidase 37
Mouse
Rat
Dog
ubiquitin specific peptidase 37
Publication Statistics
PubMed Score 22.90
PubMed score by year
PubTator Score 11.93
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title