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Tbio
USP36
Ubiquitin carboxyl-terminal hydrolase 36

Protein Summary
Description
Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402). Function as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341). Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507). Interacts to and regulates the acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312010
  • ENSP00000310590
  • ENSG00000055483
  • ENST00000542802
  • ENSP00000441214
  • ENST00000589225
  • ENSP00000467280

Symbol
  • KIAA1453
  • DUB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
histone modification site profile
0.74
transcription factor perturbation
0.74
drug perturbation
0.71
transcription factor binding site profile
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.85   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.85   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
NPM1
Tbio
Novelty:  0.0005485
p_int:  0.999998455
p_ni:  0.000001545
Score:  0.538
Data Source:  BioPlex,STRINGDB
NT5E
Tchem
Family:  Enzyme
Novelty:  0.00083237
p_int:  0.999985355
p_ni:  0.00001448
p_wrong:  1.66e-7
Score:  0.179
Data Source:  BioPlex,STRINGDB
DHX33
Tbio
Family:  Enzyme
Novelty:  0.07473852
p_int:  0.999951106
p_ni:  0.000048894
Score:  0.821
Data Source:  BioPlex,STRINGDB
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.999934651
p_ni:  0.000064788
p_wrong:  5.6e-7
Data Source:  BioPlex
KIAA0232
Tdark
Novelty:  2.37569744
p_int:  0.994526265
p_ni:  0.005473735
p_wrong:  1e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
CELSR2
Tbio
Family:  GPCR
Novelty:  0.02657319
p_int:  0.849150088
p_ni:  0.150849857
p_wrong:  5.5e-8
Score:  0.222
Data Source:  BioPlex,STRINGDB
HIST2H2BE
Tbio
Novelty:  0.00024381
Score:  0.717
Data Source:  STRINGDB
RCE1
Tchem
Family:  Enzyme
Novelty:  0.01209847
Score:  0.705
Data Source:  STRINGDB
USP28
Tchem
Family:  Enzyme
Novelty:  0.02432294
Score:  0.698
Data Source:  STRINGDB
CFAP161
Tdark
Novelty:  1.37101386
Score:  0.694
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
4
81.3
2
2
2
76.7
red blood cell distribution width
1
1
1
42.3
HbA1c measurement
1
1
1
42.3
high density lipoprotein cholesterol measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
81.3
2
76.7
red blood cell distribution width
1
42.3
HbA1c measurement
1
42.3
high density lipoprotein cholesterol measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 36
VGNC:9772
742992
Macaque
ubiquitin specific peptidase 36
710393
Mouse
MGI:1919594
72344
Rat
RGD:1309937
303700
Dog
ubiquitin specific peptidase 36
483344
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 36
Macaque
ubiquitin specific peptidase 36
Mouse
Rat
Dog
ubiquitin specific peptidase 36
Publication Statistics
PubMed Score 39.85
PubMed score by year
PubTator Score 13.88
PubTator score by year
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Related Publications
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PMID
Year
Title