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Tbio
USP35
Ubiquitin carboxyl-terminal hydrolase 35

Protein Summary
Description
This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000526425
  • ENSP00000434942
  • ENSG00000118369
  • ENST00000529308
  • ENSP00000431876

Symbol
  • KIAA1372
  • USP34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
virus perturbation
0.83
cell line
0.75
histone modification site profile
0.71
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.32   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.32   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
UBA52
Tbio
Novelty:  0.01637744
Score:  0.943
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.885
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.874
Data Source:  STRINGDB
WDR48
Tbio
Novelty:  0.04070481
Score:  0.806
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.732
Data Source:  STRINGDB
TNIP2
Tbio
Novelty:  0.03640252
Score:  0.729
Data Source:  STRINGDB
KCTD14
Tdark
Novelty:  1.19182828
Score:  0.668
Data Source:  STRINGDB
USP30
Tchem
Family:  Enzyme
Novelty:  0.03427211
Score:  0.658
Data Source:  STRINGDB
DPT
Tbio
Novelty:  0.01984221
Score:  0.655
Data Source:  STRINGDB
ALG8
Tbio
Family:  Enzyme
Novelty:  0.03721075
Score:  0.592
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
1
2
71.2
total cholesterol measurement
1
1
1
62.1
serum alanine aminotransferase measurement
2
2
1
6.2
54.2
1
1
0
1.3
44.2
L lactate dehydrogenase measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
71.2
total cholesterol measurement
1
62.1
serum alanine aminotransferase measurement
1
6.2
54.2
0
1.3
44.2
L lactate dehydrogenase measurement
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ubiquitin specific peptidase 35
700073
Mouse
MGI:2685339
244144
Rat
RGD:1565984
308834
Dog
ubiquitin specific peptidase 35
VGNC:48191
485168
Cow
ubiquitin specific peptidase 35
VGNC:36725
525702
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ubiquitin specific peptidase 35
Mouse
Rat
Dog
ubiquitin specific peptidase 35
Cow
ubiquitin specific peptidase 35
Publication Statistics
PubMed Score 14.32
PubMed score by year
PubTator Score 7.77
PubTator score by year
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Related Publications
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PMID
Year
Title