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Tbio
USP34
Ubiquitin carboxyl-terminal hydrolase 34

Protein Summary
Description
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor perturbation
0.8
tissue sample
0.73
disease perturbation
0.68
tissue
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.71   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.71   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.999997791
p_ni:  0.000002209
Score:  0.159
Data Source:  BioPlex,STRINGDB
LRRTM4
Tbio
Novelty:  0.07741851
p_int:  0.999995623
p_ni:  0.000004377
Data Source:  BioPlex
ZNF214
Tbio
Family:  TF
Novelty:  0.15323721
p_int:  0.999993592
p_ni:  0.000006408
Score:  0.256
Data Source:  BioPlex,STRINGDB
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
p_int:  0.999976861
p_ni:  0.000023138
Score:  0.204
Data Source:  BioPlex,STRINGDB
ZNF764
Tdark
Family:  TF
Novelty:  0.76308829
p_int:  0.999931352
p_ni:  0.000068648
Score:  0.198
Data Source:  BioPlex,STRINGDB
SUV39H1
Tchem
Family:  Epigenetic
Novelty:  0.00417439
p_int:  0.999882384
p_ni:  0.000117616
Score:  0.188
Data Source:  BioPlex,STRINGDB
ZNF669
Tdark
Family:  TF
Novelty:  2.09725685
p_int:  0.997541587
p_ni:  0.002458402
p_wrong:  1.1e-8
Score:  0.213
Data Source:  BioPlex,STRINGDB
ERMAP
Tbio
Novelty:  0.04270359
p_int:  0.997302515
p_ni:  0.002697485
Score:  0.208
Data Source:  BioPlex,STRINGDB
ZNF550
Tdark
Family:  TF
Novelty:  18
p_int:  0.997054463
p_ni:  0.002945529
p_wrong:  8e-9
Score:  0.198
Data Source:  BioPlex,STRINGDB
C6orf222
Tdark
Novelty:  37
p_int:  0.994144816
p_ni:  0.005855024
p_wrong:  1.61e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Signal Transduction
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Signal Transduction
Signaling by WNT
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
2
2
90.7
neutrophil count
2
2
2
89
leukocyte count
2
2
2
88.6
reticulocyte measurement
2
3
3
85.2
chronotype measurement
2
3
1
1
83.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
90.7
neutrophil count
2
89
leukocyte count
2
88.6
reticulocyte measurement
3
85.2
chronotype measurement
1
1
83.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 34
VGNC:405
100611292
Macaque
ubiquitin specific peptidase 34
718028
Mouse
MGI:109473
17847
Rat
RGD:1565181
360990
Dog
ubiquitin specific peptidase 34
VGNC:48190
474608
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 34
Macaque
ubiquitin specific peptidase 34
Mouse
Rat
Dog
ubiquitin specific peptidase 34
Publication Statistics
PubMed Score 7.71
PubMed score by year
PubTator Score 15.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title