You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
USP22
Ubiquitin carboxyl-terminal hydrolase 22

Protein Summary
Description
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261497
  • ENSP00000261497
  • ENSG00000124422
  • ENST00000537526
  • ENSP00000440950

Symbol
  • KIAA1063
  • USP3L
  • USP3L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
molecular function
0.96
kinase perturbation
0.95
transcription factor binding site profile
0.86
biological process
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.31   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.31   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0