Tbio USP22 Ubiquitin carboxyl-terminal hydrolase 22

Protein Summary

Description

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

Uniprot Accession IDs

• Q9UPT9
• A0JNS3
• Q2NLE2
• Q6MZY4
• Q8TBS8
• Q96IW5

Gene Name

• USP22

Ensembl ID

• ENST00000261497
• ENSP00000261497
• ENSG00000124422
• ENST00000537526
• ENSP00000440950

Symbol

• KIAA1063
• USP3L
• USP3L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
molecular function	0.96
kinase perturbation	0.95
transcription factor binding site profile	0.86
biological process	0.84

Protein Classes

PANTHER Classes

Protein / ... / Cysteine Protease / Ubiquitin Carboxyl-terminal Hydrolase 22

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Ubiquitin Carboxyl-terminal Hydrolase 22

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.31   (req: < 5)

Gene RIFs: 106   (req: <= 3)

Antibodies: 301   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.31   (req: >= 5)

Gene RIFs: 106   (req: > 3)

Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0