You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
USP19
Ubiquitin carboxyl-terminal hydrolase 19

Protein Summary
Description
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains. Protein ubiquitination controls many intracellular processes, inc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398888
  • ENSP00000381863
  • ENSG00000172046
  • ENST00000417901
  • ENSP00000395260
  • ENST00000434032
  • ENSP00000401197
  • ENST00000453664
  • ENSP00000400090

Symbol
  • KIAA0891
  • ZMYND9
  • ZMYND9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.89
protein domain
0.85
kinase perturbation
0.84
disease perturbation
0.83
tissue sample
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.18   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.18   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
FERD3L
Tbio
Family:  TF
Novelty:  0.06797434
p_int:  0.999992248
p_ni:  0.000007752
Score:  0.187
Data Source:  BioPlex,STRINGDB
FKBP6
Tbio
Family:  Enzyme
Novelty:  0.02240256
p_int:  0.999686494
p_ni:  0.000313506
Score:  0.353
Data Source:  BioPlex,STRINGDB
AURKC
Tchem
Family:  Kinase
Novelty:  0.00950433
p_int:  0.998263125
p_ni:  0.001736875
Score:  0.257
Data Source:  BioPlex,STRINGDB
NXNL2
Tdark
Novelty:  0.46673216
p_int:  0.989147228
p_ni:  0.010852772
Data Source:  BioPlex
IRF3
Tbio
Family:  TF
Novelty:  0.00099474
p_int:  0.979937292
p_ni:  0.020062708
Score:  0.213
Data Source:  BioPlex,STRINGDB
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.978515869
p_ni:  0.021484131
Data Source:  BioPlex
CRYL1
Tbio
Family:  Enzyme
Novelty:  0.04513297
p_int:  0.95759631
p_ni:  0.042403688
p_wrong:  2e-9
Data Source:  BioPlex
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.898883293
p_ni:  0.101116707
Score:  0.154
Data Source:  BioPlex,STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.844093504
p_ni:  0.155906496
Score:  0.33
Data Source:  BioPlex,STRINGDB
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.776754725
p_ni:  0.223245275
Score:  0.188
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
2
2
85.8
3
2
2
1
73.8
body fat distribution
2
1
4
70.5
urate measurement
1
1
1
68.3
chronotype measurement
1
1
0
1.1
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
85.8
2
1
73.8
body fat distribution
4
70.5
urate measurement
1
68.3
chronotype measurement
0
1.1
68
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 19
VGNC:2626
460364
Macaque
ubiquitin specific peptidase 19
707512
Mouse
MGI:1918722
71472
Rat
RGD:1303276
361190
Dog
ubiquitin specific peptidase 19
VGNC:48181
476627
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 19
Macaque
ubiquitin specific peptidase 19
Mouse
Rat
Dog
ubiquitin specific peptidase 19
Publication Statistics
PubMed Score 35.18
PubMed score by year
PubTator Score 13.68
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title