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Tbio
USP17L2
Ubiquitin carboxyl-terminal hydrolase 17

Protein Summary
Description
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection. DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by O ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333796
  • ENSP00000333329
  • ENSG00000223443

Symbol
  • DUB3
  • USP17
  • USP17H
  • USP17I
  • USP17J
  • USP17K
  • USP17L
  • USP17M
  • DUB3
  • DUB-3
  • USP17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
tissue sample
0.89
cellular component
0.58
protein domain
0.58
cell line
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.67   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.67   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
SUDS3
Tbio
Family:  Enzyme
Novelty:  0.03837881
Score:  0.964
Data Source:  Reactome,STRINGDB
RCE1
Tchem
Family:  Enzyme
Novelty:  0.01209847
Score:  0.961
Data Source:  Reactome,STRINGDB
CDC25A
Tchem
Family:  Enzyme
Novelty:  0.00250149
Score:  0.952
Data Source:  Reactome,STRINGDB
USP17L11
Tdark
Family:  Enzyme
Novelty:  122
Score:  0.915
Data Source:  STRINGDB
DDX58
Tbio
Family:  Enzyme
Novelty:  0.00080099
Score:  0.912
Data Source:  Reactome,STRINGDB
IFIH1
Tbio
Family:  Enzyme
Novelty:  0.00111499
Score:  0.906
Data Source:  Reactome,STRINGDB
USP17L22
Tdark
Family:  Enzyme
Novelty:  32
Score:  0.906
Data Source:  STRINGDB
USP17L4
Tdark
Family:  Enzyme
Novelty:  11.52
Score:  0.903
Data Source:  STRINGDB
USP17L20
Tdark
Family:  Enzyme
Novelty:  6
Score:  0.902
Data Source:  STRINGDB
USP17L1
Tdark
Family:  Enzyme
Novelty:  2.66694594
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deubiquitination (R-HSA-5688426)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
3
3
91.3
appendicular lean mass
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
91.3
appendicular lean mass
1
21.5
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 21.67
PubMed score by year
PubTator Score 8.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title