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Tbio
USP16
Ubiquitin carboxyl-terminal hydrolase 16

Protein Summary
Description
Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding differ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334352
  • ENSP00000334808
  • ENSG00000156256
  • ENST00000399975
  • ENSP00000382857
  • ENST00000399976
  • ENSP00000382858

Symbol
  • UBPM
  • UBP-M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
kinase perturbation
0.91
disease perturbation
0.9
biological process
0.88
molecular function
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.41   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.41   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
ALPG
Tchem
Family:  Enzyme
Novelty:  0.00577814
p_int:  1
Score:  0.214
Data Source:  BioPlex,STRINGDB
G0S2
Tbio
Novelty:  0.02273959
p_int:  0.999989277
p_ni:  0.00001071
p_wrong:  1.2e-8
Data Source:  BioPlex
APOM
Tbio
Novelty:  0.00505937
p_int:  0.999711318
p_ni:  0.000288637
p_wrong:  4.5e-8
Score:  0.345
Data Source:  BioPlex,STRINGDB
NEURL4
Tdark
Novelty:  0.20430708
p_int:  0.999275418
p_ni:  0.000724582
Score:  0.177
Data Source:  BioPlex,STRINGDB
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
p_int:  0.996024081
p_ni:  0.003975919
Score:  0.393
Data Source:  BioPlex,STRINGDB
WDR54
Tdark
Novelty:  1.19807122
p_int:  0.966142329
p_ni:  0.033857671
Score:  0.165
Data Source:  BioPlex,STRINGDB
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.938962934
p_ni:  0.000499645
p_wrong:  0.060537421
Data Source:  BioPlex
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.957
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.951
Data Source:  STRINGDB
USP21
Tbio
Family:  Enzyme
Novelty:  0.11434352
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (29)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
1
3
80.9
reticulocyte count
2
1
2
80.2
serum gamma-glutamyl transferase measurement
2
2
2
75.4
leukocyte count
1
1
1
40.7
electrocardiography
1
1
3
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
80.9
reticulocyte count
2
80.2
serum gamma-glutamyl transferase measurement
2
75.4
leukocyte count
1
40.7
electrocardiography
3
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 16
VGNC:1115
458497
Macaque
ubiquitin specific peptidase 16
706403
Mouse
MGI:1921362
74112
Rat
RGD:1307192
288306
Dog
ubiquitin specific peptidase 16
VGNC:53051
478398
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 16
Macaque
ubiquitin specific peptidase 16
Mouse
Rat
Dog
ubiquitin specific peptidase 16
Publication Statistics
PubMed Score 9.41
PubMed score by year
PubTator Score 9.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title