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Tchem
USP14
Ubiquitin carboxyl-terminal hydrolase 14

Protein Summary
Description
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation. This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme ( ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261601
  • ENSP00000261601
  • ENSG00000101557
  • ENST00000400266
  • ENSP00000383125
  • ENST00000582707
  • ENSP00000464447

Symbol
  • TGT
  • TGT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
disease perturbation
0.93
molecular function
0.91
protein domain
0.85
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.58   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.58   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (202)
AHNAK2
Tbio
Novelty:  0.05663435
p_int:  0.858689313
p_ni:  0.141310687
Score:  0.199
Data Source:  BioPlex,STRINGDB
CNTN1
Tbio
Novelty:  0.00741212
p_int:  0.815667773
p_ni:  0.184202606
p_wrong:  0.000129621
Score:  0.221
Data Source:  BioPlex,STRINGDB
AHNAK
Tbio
Novelty:  0.01201996
p_int:  0.782230429
p_ni:  0.217769571
Score:  0.242
Data Source:  BioPlex,STRINGDB
PSMD8
Tbio
Family:  Enzyme
Novelty:  0.03053455
Score:  0.999
Data Source:  STRINGDB
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
Score:  0.999
Data Source:  STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
Score:  0.999
Data Source:  STRINGDB
PSMD2
Tbio
Family:  Enzyme
Novelty:  0.03530762
Score:  0.999
Data Source:  STRINGDB
PSMC4
Tchem
Family:  Enzyme
Novelty:  0.01717597
Score:  0.999
Data Source:  STRINGDB
PSMC6
Tbio
Family:  Enzyme
Novelty:  0.00168013
Score:  0.999
Data Source:  STRINGDB
PSMD1
Tbio
Family:  Enzyme
Novelty:  0.02168311
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
72.5
triglyceride measurement
2
2
2
37.3
red blood cell distribution width
2
1
2
13.1
age at menarche
1
1
1
5.3
high density lipoprotein cholesterol measurement
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
72.5
triglyceride measurement
2
37.3
red blood cell distribution width
2
13.1
age at menarche
1
5.3
high density lipoprotein cholesterol measurement
1
3.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 14
VGNC:8873
455325
Macaque
ubiquitin specific peptidase 14
698087
Mouse
MGI:1928898
59025
Rat
RGD:1311825
291796
Dog
ubiquitin specific peptidase 14
VGNC:48179
480182
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 14
Macaque
ubiquitin specific peptidase 14
Mouse
Rat
Dog
ubiquitin specific peptidase 14
Publication Statistics
PubMed Score 142.58
PubMed score by year
PubTator Score 62.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title