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Tbio
USP12
Ubiquitin carboxyl-terminal hydrolase 12

Protein Summary
Description
Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity (PubMed:19075014, PubMed:27373336). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014). In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282344
  • ENSP00000282344
  • ENSG00000152484

Symbol
  • UBH1
  • USP12L1
  • UBH1
  • USP12L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
microRNA
0.76
cell type or tissue
0.64
transcription factor
0.64
histone modification site profile
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.69   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.69   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.999888128
p_ni:  0.000111865
p_wrong:  7e-9
Data Source:  BioPlex
VSX2
Tbio
Family:  TF
Novelty:  0.0046733
p_int:  0.999815381
p_ni:  0.000184608
p_wrong:  1.2e-8
Score:  0.527
Data Source:  BioPlex,STRINGDB
GORASP1
Tbio
Novelty:  0.02332405
p_int:  0.990923068
p_ni:  0.00298864
p_wrong:  0.006088292
Data Source:  BioPlex
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
p_int:  0.984070347
p_ni:  0.01582687
p_wrong:  0.000102783
Score:  0.177
Data Source:  BioPlex,STRINGDB
GPR161
Tbio
Family:  GPCR
Novelty:  0.00235739
p_int:  0.934456247
p_ni:  0.064966593
p_wrong:  0.00057716
Data Source:  BioPlex
PHF8
Tchem
Family:  Epigenetic
Novelty:  0.01946151
p_int:  0.902178432
p_ni:  0.065784122
p_wrong:  0.032037446
Data Source:  BioPlex
VSX1
Tbio
Family:  TF
Novelty:  0.01213324
p_int:  0.86198408
p_ni:  0.031058306
p_wrong:  0.106957614
Score:  0.23
Data Source:  BioPlex,STRINGDB
HSPB9
Tbio
Novelty:  0.09680405
p_int:  0.860910048
p_ni:  0.009094521
p_wrong:  0.129995431
Score:  0.188
Data Source:  BioPlex,STRINGDB
WDR48
Tbio
Novelty:  0.04070481
Score:  0.999
Data Source:  Reactome,STRINGDB
WDR20
Tbio
Novelty:  0.03031804
Score:  0.994
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
88.7
creatinine measurement
1
1
1
49.5
glomerular filtration rate
1
1
1
48.5
aspartate aminotransferase measurement
1
1
0
5.8
27.3
monocyte percentage of leukocytes
1
1
1
9.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
88.7
creatinine measurement
1
49.5
glomerular filtration rate
1
48.5
aspartate aminotransferase measurement
0
5.8
27.3
monocyte percentage of leukocytes
1
9.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 12
VGNC:13155
735835
Macaque
ubiquitin specific peptidase 12
721611
Mouse
MGI:1270128
22217
Rat
RGD:1308045
360763
Dog
ubiquitin specific peptidase 12
486033
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 12
Macaque
ubiquitin specific peptidase 12
Mouse
Rat
Dog
ubiquitin specific peptidase 12
Publication Statistics
PubMed Score 24.69
PubMed score by year
PubTator Score 9.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title