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Tbio
USH1G
Usher syndrome type-1G protein

Protein Summary
Description
Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. This gene encodes a protein that contains three ankyrin domains, a class I PDZ-binding motif and a sterile alpha motif. The encoded protein interacts with harmonin, which is associated with Usher syndrome type 1C. This protein plays a role in the development and maintenance of the auditory and visual systems and functions in the cohesion of hair bundles formed by inner ear sensory cells. Mutations in this gene are associated with Usher syndrome type 1G (USH1G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000614341
  • ENSP00000480279
  • ENSG00000182040

Symbol
  • SANS
  • SANS
  • ANKS4A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
protein domain
0.73
cell line
0.52
microRNA
0.49
transcription factor
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.49   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.49   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
USH1C
Tbio
Novelty:  0.01066917
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
MICAL1
Tbio
Family:  Enzyme
Novelty:  0.02668048
p_int:  0.998568376
p_ni:  0.001431588
p_wrong:  3.6e-8
Score:  0.408
Data Source:  BioPlex,STRINGDB
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.996349958
p_ni:  0.00365002
p_wrong:  2.3e-8
Score:  0.251
Data Source:  BioPlex,STRINGDB
PCDH15
Tbio
Novelty:  0.0097699
Score:  0.902
Data Source:  STRINGDB
MYO7A
Tbio
Novelty:  0.00314435
Score:  0.894
Data Source:  STRINGDB
CDH23
Tbio
Novelty:  0.00588227
Score:  0.882
Data Source:  STRINGDB
WHRN
Tbio
Novelty:  0.01886351
Score:  0.873
Data Source:  STRINGDB
USH2A
Tbio
Novelty:  0.00223387
Score:  0.853
Data Source:  STRINGDB
CLRN1
Tbio
Novelty:  0.03334995
Score:  0.852
Data Source:  STRINGDB
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
Score:  0.833
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ferritin measurement
1
1
1
55.2
intraocular pressure measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ferritin measurement
1
55.2
intraocular pressure measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2450757
16470
Rat
RGD:1304551
287819
Dog
USH1 protein network component sans
VGNC:48173
609705
Horse
USH1 protein network component sans
VGNC:24826
100052352
Cow
USH1 protein network component sans
VGNC:36705
531104
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
USH1 protein network component sans
Horse
USH1 protein network component sans
Cow
USH1 protein network component sans
Publication Statistics
PubMed Score 29.49
PubMed score by year
PubTator Score 841.97
PubTator score by year
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Related Publications
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PMID
Year
Title