Tbio USF2 Upstream stimulatory factor 2

Protein Summary

Description

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q15853
• O00671
• O00709
• Q05750
• Q07952
• Q15851
• Q15852
• Q6FI33
• Q6YI47

Gene Name

• USF2

Ensembl ID

• ENST00000222305
• ENSP00000222305
• ENSG00000105698
• ENST00000343550
• ENSP00000340633
• ENST00000379134
• ENSP00000368429
• ENST00000595068
• ENSP00000471099

Symbol

• BHLHB12
• FIP
• bHLHb12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
molecular function	0.91
disease perturbation	0.9
biological process	0.68
transcription factor binding site profile	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.57   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 344   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.57   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0