Tbio USF2 Upstream stimulatory factor 2

Protein Summary

Description

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q15853
• O00671
• O00709
• Q05750
• Q07952
• Q15851
• Q15852
• Q6FI33
• Q6YI47

Gene Name

• USF2

Ensembl ID

• ENST00000222305
• ENSP00000222305
• ENSG00000105698
• ENST00000343550
• ENSP00000340633
• ENST00000379134
• ENSP00000368429
• ENST00000595068
• ENSP00000471099

Symbol

• BHLHB12
• FIP
• bHLHb12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
molecular function	0.91
disease perturbation	0.9
biological process	0.68
transcription factor binding site profile	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.79   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 344   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.79   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

USF1

Tbio

Family:  TF

Novelty:  0.00136587

p_int:  1

Score:  0.987

Data Source:  BioPlex,STRINGDB

CCDC102B

Tdark

Novelty:  0.28075569

p_int:  0.999993798

p_ni:  0.000005925

p_wrong:  2.77e-7

Score:  0.181

Data Source:  BioPlex,STRINGDB

CALML3

Tbio

Novelty:  0.0336689

p_int:  0.998355639

p_ni:  0.000135305

p_wrong:  0.001509056

Data Source:  BioPlex

FOSL2

Tbio

Family:  TF

Novelty:  0.00375452

p_int:  0.997363327

p_ni:  0.002326216

p_wrong:  0.000310456

Score:  0.321

Data Source:  BioPlex,STRINGDB

ADAM18

Tdark

Family:  Enzyme

Novelty:  0.22622379

p_int:  0.987604238

p_ni:  0.000033047

p_wrong:  0.012362715

Data Source:  BioPlex

ADAMTS12

Tbio

Family:  Enzyme

Novelty:  0.03184816

p_int:  0.93258839

p_ni:  0.000138513

p_wrong:  0.067273097

Score:  0.823

Data Source:  BioPlex,STRINGDB

EP300

Tchem

Family:  Epigenetic

Novelty:  0.00055009

Score:  0.957

Data Source:  STRINGDB

SP1

Tbio

Family:  TF

Novelty:  0.0007915

Score:  0.936

Data Source:  STRINGDB

FOSL1

Tbio

Family:  TF

Novelty:  0.00294254

Score:  0.924

Data Source:  STRINGDB

ESR1

Tclin

Family:  NR

Novelty:  0.00005938

Score:  0.921

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (27)

Reactome (4)

PathwayCommons (2)

WikiPathways (21)

ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ESR-mediated signaling	189 targets	R-HSA-8939211
Reactome	Estrogen-dependent gene expression	119 targets	R-HSA-9018519
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by Nuclear Receptors	232 targets	R-HSA-9006931

Name	Explore in Pharos	Explore in Source
ESR-mediated signaling	189 targets	R-HSA-8939211
Estrogen-dependent gene expression	119 targets	R-HSA-9018519
Signal Transduction	2704 targets	R-HSA-162582
Signaling by Nuclear Receptors	232 targets	R-HSA-9006931

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (7)

Components (3)

Processes (7)

Find Similar Targets

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
sequence-specific DNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
bHLH transcription factor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
protein heterodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
protein homodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Inferred from Mutant Phenotype (IMP)	BHF-UCL
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA-binding transcription factor activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations (null)

No disease associations found

GWAS Traits (10)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3	3	3		93.3
red blood cell distribution width	EFO_0005192	4	5	7		92.3
reticulocyte count	EFO_0007986	7	3	7		92
reticulocyte measurement	EFO_0010700	3	2	3		83.3
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		73.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3		93.3
red blood cell distribution width	EFO_0005192	7		92.3
reticulocyte count	EFO_0007986	7		92
reticulocyte measurement	EFO_0010700	3		83.3
mean corpuscular hemoglobin concentration	EFO_0004528	1		73.5

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
DNA-binding
Nucleus
Reference proteome
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
age-related hearing impairment
erythrocyte count
lymphocyte count
mean corpuscular hemoglobin concentration
mean platelet volume
platelet count
red blood cell density measurement
red blood cell distribution width
reticulocyte count
reticulocyte measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
growth/size/body region phenotype
integument phenotype
limbs/digits/tail phenotype
mortality/aging
nervous system phenotype
pigmentation phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	upstream transcription factor 2, c-fos interacting	VGNC:14761	101057082
Macaque	upstream transcription factor 2, c-fos interacting		718527
Mouse	upstream transcription factor 2	MGI:99961	22282
Dog	upstream transcription factor 2, c-fos interacting	VGNC:53999	612662
Cow	upstream transcription factor 2, c-fos interacting		407240

Species	Name	OMA	EggNOG	Inparanoid
Chimp	upstream transcription factor 2, c-fos interacting
Macaque	upstream transcription factor 2, c-fos interacting
Mouse	upstream transcription factor 2
Dog	upstream transcription factor 2, c-fos interacting
Cow	upstream transcription factor 2, c-fos interacting

Publication Statistics

PubMed Score 181.79

PubMed score by year

Reset Zoom

PubTator Score 225.08

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (66)

GeneRif Annotations (37)

Items per page:

10

0 of 0

PMID	Year	Title