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Tbio
URI1
Unconventional prefoldin RPB5 interactor 1

Protein Summary
Description
Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene ex ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360605
  • ENSP00000353817
  • ENSG00000105176
  • ENST00000392271
  • ENSP00000376097

Symbol
  • C19orf2
  • NNX3
  • PPP1R19
  • RMP
  • URI
  • RMP
  • URI
  • NNX3
  • C19orf2
  • PPP1R19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.95
biological process
0.84
cell type or tissue
0.77
molecular function
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.8   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.8   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
PIH1D1
Tbio
Novelty:  0.10737369
p_int:  0.999968472
p_ni:  0.000031528
Score:  0.821
Data Source:  BioPlex,STRINGDB
UXT
Tbio
Novelty:  0.0272609
p_int:  0.999923991
p_ni:  0.000076009
Score:  0.965
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999911557
p_ni:  0.000088443
Score:  0.601
Data Source:  BioPlex,STRINGDB
RPAP3
Tbio
Family:  Enzyme
Novelty:  0.02003375
p_int:  0.999595203
p_ni:  0.000404797
Score:  0.71
Data Source:  BioPlex,STRINGDB
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.998927782
p_ni:  0.001072218
Score:  0.392
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.998354209
p_ni:  0.001645759
p_wrong:  3.2e-8
Score:  0.651
Data Source:  BioPlex,STRINGDB
PFDN2
Tbio
Novelty:  0.08537716
p_int:  0.993547128
p_ni:  0.006452872
Score:  0.92
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.978283868
p_ni:  0.021716118
p_wrong:  1.3e-8
Score:  0.797
Data Source:  BioPlex,STRINGDB
RUVBL2
Tbio
Novelty:  0.01129017
p_int:  0.965957009
p_ni:  0.03404299
p_wrong:  1e-9
Score:  0.748
Data Source:  BioPlex,STRINGDB
ZBBX
Tdark
Novelty:  1.66474399
p_int:  0.914033777
p_ni:  0.085966223
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
39.4
monocyte percentage of leukocytes
1
1
1
4.6
urate measurement
1
1
1
0.6
cognitive function measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
39.4
monocyte percentage of leukocytes
1
4.6
urate measurement
1
0.6
cognitive function measurement
1
0.1
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
URI1, prefoldin like chaperone
700838
Mouse
MGI:1342294
19777
Rat
RGD:1310358
308537
Dog
URI1, prefoldin like chaperone
VGNC:48166
476501
Horse
URI1, prefoldin like chaperone
VGNC:24819
100053932
Species
Name
OMA
EggNOG
Inparanoid
Macaque
URI1, prefoldin like chaperone
Mouse
Rat
Dog
URI1, prefoldin like chaperone
Horse
URI1, prefoldin like chaperone
Publication Statistics
PubMed Score 29.80
PubMed score by year
PubTator Score 19.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title