You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
URGCP
Up-regulator of cell proliferation

Protein Summary
Description
May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336086
  • ENSP00000336872
  • ENSG00000106608
  • ENST00000402306
  • ENSP00000384955
  • ENST00000443736
  • ENSP00000392136
  • ENST00000453200
  • ENSP00000396918

Symbol
  • KIAA1507
  • URG4
  • URG4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
interacting protein
0.85
transcription factor binding site profile
0.78
molecular function
0.73
cell line
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.7   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.7   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
UBE2D1
Tbio
Novelty:  0.00865867
p_int:  0.99999996
p_ni:  4e-8
Data Source:  BioPlex
UBE2D4
Tbio
Novelty:  0.40836104
p_int:  0.999999944
p_ni:  5.6e-8
Data Source:  BioPlex
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.999582947
p_ni:  0.000017371
p_wrong:  0.000399683
Score:  0.199
Data Source:  BioPlex,STRINGDB
RTRAF
Tbio
Novelty:  0.03996206
Score:  0.693
Data Source:  STRINGDB
CCND1
Tchem
Novelty:  0.0001186
Score:  0.634
Data Source:  STRINGDB
CISD2
Tbio
Novelty:  0.01665752
Score:  0.538
Data Source:  STRINGDB
MMP9
Tchem
Family:  Enzyme
Novelty:  0.00008645
Score:  0.521
Data Source:  STRINGDB
ZNF366
Tbio
Family:  TF
Novelty:  0.1166487
Score:  0.502
Data Source:  STRINGDB
WDFY1
Tbio
Novelty:  0.13382544
Score:  0.497
Data Source:  STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.477
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
1
1
70.2
mean platelet volume
1
1
1
45.7
vitamin D measurement
1
1
1
29
peak insulin response measurement
1
2
2
17.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
70.2
mean platelet volume
1
45.7
vitamin D measurement
1
29
peak insulin response measurement
2
17.4
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
upregulator of cell proliferation
VGNC:8786
100610816
Macaque
upregulator of cell proliferation [Source:HGNC Symbol;Acc:HGNC:30890]
Mouse
MGI:1919296
72046
Rat
RGD:1564681
305493
Dog
up-regulator of cell proliferation
610578
Species
Name
OMA
EggNOG
Inparanoid
Chimp
upregulator of cell proliferation
Macaque
upregulator of cell proliferation [Source:HGNC Symbol;Acc:HGNC:30890]
Mouse
Rat
Dog
up-regulator of cell proliferation
Publication Statistics
PubMed Score 30.70
PubMed score by year
PubTator Score 23.30
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title