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Tbio
URB2
Unhealthy ribosome biogenesis protein 2 homolog

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258243
  • ENSP00000258243
  • ENSG00000135763

Symbol
  • KIAA0133
  • NPA2
  • NET10
  • KIAA0133
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
virus perturbation
0.72
tissue sample
0.69
cell line
0.66
cellular component
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.79   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.79   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
NOL8
Tbio
Novelty:  0.28065454
p_int:  0.999850268
p_ni:  0.000149732
Score:  0.773
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.995731427
p_ni:  0.004268573
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.992501068
p_ni:  0.007498932
Data Source:  BioPlex
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.985417778
p_ni:  0.014582222
Data Source:  BioPlex
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.98271629
p_ni:  0.01728371
Score:  0.285
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.961668152
p_ni:  0.038331848
Score:  0.234
Data Source:  BioPlex,STRINGDB
ZNF512
Tbio
Family:  TF
Novelty:  0.08783629
p_int:  0.949449329
p_ni:  0.050550671
Score:  0.177
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.868625357
p_ni:  0.131374643
Data Source:  BioPlex
CCDC59
Tbio
Novelty:  0.05894885
p_int:  0.846372799
p_ni:  0.153627201
Data Source:  BioPlex
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.831220645
p_ni:  0.168779355
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
5
1
4
1.1
82.8
mean corpuscular volume
1
1
1
67.3
mean reticulocyte volume
1
1
1
63.7
glucose measurement
3
1
3
62.3
mean corpuscular hemoglobin concentration
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
4
1.1
82.8
mean corpuscular volume
1
67.3
mean reticulocyte volume
1
63.7
glucose measurement
3
62.3
mean corpuscular hemoglobin concentration
1
62.1
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
740652
Macaque
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
694893
Mouse
MGI:2681124
382038
Rat
RGD:1307980
292087
Dog
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
479207
Species
Name
OMA
EggNOG
Inparanoid
Chimp
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
Macaque
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
Mouse
Rat
Dog
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
Publication Statistics
PubMed Score 29.79
PubMed score by year
PubTator Score 5.87
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title