Tbio UQCRQ Cytochrome b-c1 complex subunit 8

Protein Summary

Description

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14949
• Q5FVE2
• Q9BV88
• Q9T2V7

Gene Name

• UQCRQ

Ensembl ID

• ENST00000378665
• ENSP00000367934
• ENSG00000164405
• ENST00000378667
• ENSP00000367936
• ENST00000378670
• ENSP00000367939

Symbol

• QPC
• QCR8
• QP-C
• UQCR7
• MC3DN4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
kinase perturbation	0.95
histone modification site profile	0.9
virus perturbation	0.85
transcription factor binding site profile	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.57   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.57   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (227)

Explore Interacting Targets

1 – 10 of 227

• See Interactions on String-DB

UQCRB

Tbio

Novelty:  0.02933046

p_int:  0.999999148

p_ni:  8.52e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

COX7A2L

Tbio

Family:  Enzyme

Novelty:  0.06920916

p_int:  0.999974431

p_ni:  0.000025569

Score:  0.982

Data Source:  BioPlex,STRINGDB

MT-CYB

Tbio

Novelty:  0.00012093

p_int:  0.999972982

p_ni:  0.000026836

p_wrong:  1.82e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

IGHA2

Tbio

p_int:  0.999792505

p_ni:  0.000207478

p_wrong:  1.7e-8

Data Source:  BioPlex

BPIFA2

Tbio

Novelty:  0.01533858

p_int:  0.99965776

p_ni:  0.000320802

p_wrong:  0.000021438

Data Source:  BioPlex

CST1

Tbio

Novelty:  0.02399609

p_int:  0.999003862

p_ni:  0.000996026

p_wrong:  1.13e-7

Data Source:  BioPlex

COX6B1

Tbio

Family:  Enzyme

Novelty:  0.02531055

p_int:  0.998700791

p_ni:  0.001298726

p_wrong:  4.82e-7

Score:  0.989

Data Source:  BioPlex,STRINGDB

UQCRC1

Tbio

Family:  Enzyme

Novelty:  0.01746759

p_int:  0.995885314

p_ni:  0.004114686

Score:  0.999

Data Source:  BioPlex,STRINGDB

COX4I1

Tbio

Family:  Enzyme

Novelty:  0.00208873

p_int:  0.994897744

p_ni:  0.00510224

p_wrong:  1.6e-8

Score:  0.973

Data Source:  BioPlex,STRINGDB

NAT8B

Tbio

Family:  Enzyme

p_int:  0.99384279

p_ni:  0.006035239

p_wrong:  0.000121971

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (14)

Reactome (4)

KEGG (8)

WikiPathways (2)

Metabolism (R-HSA-1430728)

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Find Similar Targets

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5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Respiratory electron transport	101 targets	R-HSA-611105
Reactome	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
Reactome	The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Respiratory electron transport	101 targets	R-HSA-611105
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (1)

Components (3)

Processes (9)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
ubiquinol-cytochrome-c reductase activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (14)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
childhood onset asthma	MONDO_0005405	1	1	0	1.1	74.9
blood protein measurement	EFO_0007937	1	1	1		68.6
glomerular filtration rate	EFO_0005208	3	1	3		68.3
asthma	MONDO_0004979	1	1	0	1.1	61
alcohol consumption measurement	EFO_0007878	2	2	2		59.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
childhood onset asthma	MONDO_0005405	0	1.1	74.9
blood protein measurement	EFO_0007937	1		68.6
glomerular filtration rate	EFO_0005208	3		68.3
asthma	MONDO_0004979	0	1.1	61
alcohol consumption measurement	EFO_0007878	2		59.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Disease mutation
Electron transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
alcohol use disorder measurement
asthma
blood protein measurement
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body height
C-reactive protein measurement
childhood onset asthma
corneal resistance factor

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	ubiquinol-cytochrome c reductase, complex III subunit VII	MGI:107807	22272
Rat	ubiquinol-cytochrome c reductase, complex III subunit VII	RGD:1562350	497902
Dog	ubiquinol-cytochrome c reductase complex III subunit VII	VGNC:48165	609744
Cow	ubiquinol-cytochrome c reductase complex III subunit VII	VGNC:36697	286885
Pig	cytochrome b-c1 complex subunit 8		100524308

Species	Name	OMA	EggNOG	Inparanoid
Mouse	ubiquinol-cytochrome c reductase, complex III subunit VII
Rat	ubiquinol-cytochrome c reductase, complex III subunit VII
Dog	ubiquinol-cytochrome c reductase complex III subunit VII
Cow	ubiquinol-cytochrome c reductase complex III subunit VII
Pig	cytochrome b-c1 complex subunit 8

Publication Statistics

PubMed Score 30.57

PubMed score by year

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PubTator Score 4.92

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (4)

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10

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PMID	Year	Title