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Tbio
UQCRQ
Cytochrome b-c1 complex subunit 8

Protein Summary
Description
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378665
  • ENSP00000367934
  • ENSG00000164405
  • ENST00000378667
  • ENSP00000367936
  • ENST00000378670
  • ENSP00000367939

Symbol
  • QPC
  • QCR8
  • QP-C
  • UQCR7
  • MC3DN4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.95
histone modification site profile
0.9
virus perturbation
0.85
transcription factor binding site profile
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.57   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.57   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (227)
UQCRB
Tbio
Novelty:  0.02933046
p_int:  0.999999148
p_ni:  8.52e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
COX7A2L
Tbio
Family:  Enzyme
Novelty:  0.06920916
p_int:  0.999974431
p_ni:  0.000025569
Score:  0.982
Data Source:  BioPlex,STRINGDB
MT-CYB
Tbio
Novelty:  0.00012093
p_int:  0.999972982
p_ni:  0.000026836
p_wrong:  1.82e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
IGHA2
Tbio
p_int:  0.999792505
p_ni:  0.000207478
p_wrong:  1.7e-8
Data Source:  BioPlex
BPIFA2
Tbio
Novelty:  0.01533858
p_int:  0.99965776
p_ni:  0.000320802
p_wrong:  0.000021438
Data Source:  BioPlex
CST1
Tbio
Novelty:  0.02399609
p_int:  0.999003862
p_ni:  0.000996026
p_wrong:  1.13e-7
Data Source:  BioPlex
COX6B1
Tbio
Family:  Enzyme
Novelty:  0.02531055
p_int:  0.998700791
p_ni:  0.001298726
p_wrong:  4.82e-7
Score:  0.989
Data Source:  BioPlex,STRINGDB
UQCRC1
Tbio
Family:  Enzyme
Novelty:  0.01746759
p_int:  0.995885314
p_ni:  0.004114686
Score:  0.999
Data Source:  BioPlex,STRINGDB
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.994897744
p_ni:  0.00510224
p_wrong:  1.6e-8
Score:  0.973
Data Source:  BioPlex,STRINGDB
NAT8B
Tbio
Family:  Enzyme
p_int:  0.99384279
p_ni:  0.006035239
p_wrong:  0.000121971
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
1
1
0
1.1
74.9
blood protein measurement
1
1
1
68.6
glomerular filtration rate
3
1
3
68.3
asthma
1
1
0
1.1
61
alcohol consumption measurement
2
2
2
59.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1.1
74.9
blood protein measurement
1
68.6
glomerular filtration rate
3
68.3
asthma
0
1.1
61
alcohol consumption measurement
2
59.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107807
22272
Rat
RGD:1562350
497902
Dog
ubiquinol-cytochrome c reductase complex III subunit VII
VGNC:48165
609744
Cow
ubiquinol-cytochrome c reductase complex III subunit VII
VGNC:36697
286885
Pig
cytochrome b-c1 complex subunit 8
100524308
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ubiquinol-cytochrome c reductase complex III subunit VII
Cow
ubiquinol-cytochrome c reductase complex III subunit VII
Pig
cytochrome b-c1 complex subunit 8
Publication Statistics
PubMed Score 30.57
PubMed score by year
PubTator Score 4.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title