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Tbio
UQCC2
Ubiquinol-cytochrome-c reductase complex assembly factor 2

Protein Summary
Description
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability. This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000607484
  • ENSP00000476140
  • ENSG00000137288

Symbol
  • C6orf125
  • MNF1
  • M19
  • Cbp6
  • MNF1
  • MC3DN7
  • C6orf125
  • C6orf126
  • bA6B20.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
small molecule perturbation
0.82
biological process
0.71
transcription factor binding site profile
0.71
histone modification site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.71   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.71   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
UQCC1
Tbio
Family:  Enzyme
Novelty:  0.03937066
p_int:  0.999908502
p_ni:  0.000091498
Score:  0.964
Data Source:  BioPlex,STRINGDB
COX20
Tbio
Family:  Enzyme
Novelty:  0.04884442
p_int:  0.993065203
p_ni:  0.006934633
p_wrong:  1.65e-7
Score:  0.813
Data Source:  BioPlex,STRINGDB
TM2D2
Tdark
Novelty:  0.10390283
p_int:  0.936385084
p_ni:  0.063614916
Score:  0.665
Data Source:  BioPlex,STRINGDB
YARS2
Tbio
Family:  Enzyme
Novelty:  0.00522139
p_int:  0.935685638
p_ni:  0.064306042
p_wrong:  0.00000832
Score:  0.222
Data Source:  BioPlex,STRINGDB
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.916991752
p_ni:  0.082979996
p_wrong:  0.000028252
Data Source:  BioPlex
P3H1
Tbio
Family:  Enzyme
Novelty:  0.02067711
p_int:  0.895783966
p_ni:  0.104205939
p_wrong:  0.000010095
Score:  0.524
Data Source:  BioPlex,STRINGDB
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.841820606
p_ni:  0.156697997
p_wrong:  0.001481397
Data Source:  BioPlex
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.8149597
p_ni:  0.183994291
p_wrong:  0.001046009
Data Source:  BioPlex
CDR2
Tbio
Novelty:  0.00141419
p_int:  0.809630569
p_ni:  0.189786843
p_wrong:  0.000582588
Score:  0.177
Data Source:  BioPlex,STRINGDB
CPT1A
Tchem
Family:  Enzyme
Novelty:  0.00281783
p_int:  0.78624377
p_ni:  0.21375592
p_wrong:  3.1e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphorus measurement
2
2
2
88.9
platelet crit
2
2
2
78.8
self reported educational attainment
2
2
2
78.3
schizophrenia
3
2
1
1.1
76.6
HMG CoA reductase inhibitor use measurement
1
1
1
67.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphorus measurement
2
88.9
platelet crit
2
78.8
self reported educational attainment
2
78.3
schizophrenia
1
1.1
76.6
HMG CoA reductase inhibitor use measurement
1
67.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquinol-cytochrome c reductase complex assembly factor 2
VGNC:7938
100615289
Macaque
mitochondrial nucleoid factor 1
100425666
Mouse
MGI:1914517
67267
Rat
RGD:1306917
361805
Rat
RGD:1561671
361214
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquinol-cytochrome c reductase complex assembly factor 2
Macaque
mitochondrial nucleoid factor 1
Mouse
Rat
Rat
Publication Statistics
PubMed Score 83.71
PubMed score by year
PubTator Score 19.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title