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Tbio
UPRT
Uracil phosphoribosyltransferase homolog

Protein Summary
Description
This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373383
  • ENSP00000362481
  • ENSG00000094841
  • ENST00000462237
  • ENSP00000433987

Symbol
  • UPP
  • FUR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.71
tissue sample
0.6
histone modification site profile
0.59
hub protein
0.58
microRNA
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.3   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.3   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
UCK2
Tbio
Family:  Kinase
Novelty:  0.02417595
p_int:  0.999999997
p_ni:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
UCKL1
Tbio
Family:  Kinase
Novelty:  0.18522799
p_int:  0.999999408
p_ni:  5.92e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
UCK1
Tbio
Family:  Kinase
Novelty:  0.10536869
p_int:  0.999999078
p_ni:  9.22e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
p_int:  0.999959193
p_ni:  0.00000531
p_wrong:  0.000035497
Score:  0.686
Data Source:  BioPlex,STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999916518
p_ni:  0.00008332
p_wrong:  1.63e-7
Score:  0.377
Data Source:  BioPlex,STRINGDB
IRF2BP2
Tbio
Novelty:  0.06703794
p_int:  0.954710132
p_ni:  0.045289868
Score:  0.243
Data Source:  BioPlex,STRINGDB
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.781409563
p_ni:  0.218590437
Data Source:  BioPlex
UPP1
Tchem
Family:  Enzyme
Novelty:  0.01384975
Score:  0.976
Data Source:  STRINGDB
TYMP
Tclin
Family:  Enzyme
Novelty:  0.0015906
Score:  0.968
Data Source:  STRINGDB
UMPS
Tclin
Family:  Enzyme
Novelty:  0.00848756
Score:  0.968
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
35
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uracil phosphoribosyltransferase homolog
VGNC:2662
465722
Macaque
uracil phosphoribosyltransferase homolog
704157
Mouse
MGI:2685620
331487
Rat
RGD:1564806
317237
Dog
uracil phosphoribosyltransferase homolog
VGNC:48158
480960
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uracil phosphoribosyltransferase homolog
Macaque
uracil phosphoribosyltransferase homolog
Mouse
Rat
Dog
uracil phosphoribosyltransferase homolog
Publication Statistics
PubMed Score 228.30
PubMed score by year
PubTator Score 34.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title