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Tbio
UPP2
Uridine phosphorylase 2

Protein Summary
Description
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000005756
  • ENSP00000005756
  • ENSG00000007001
  • ENST00000605860
  • ENSP00000474090

Symbol
  • UP2
  • UPASE2
  • UDRPASE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.71
gene perturbation
0.62
protein domain
0.58
transcription factor
0.58
microRNA
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.76   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.76   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
TYMP
Tclin
Family:  Enzyme
Novelty:  0.0015906
Score:  0.967
Data Source:  STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
Score:  0.961
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.955
Data Source:  STRINGDB
UCK1
Tbio
Family:  Kinase
Novelty:  0.10536869
Score:  0.954
Data Source:  STRINGDB
UPRT
Tbio
Family:  Enzyme
Novelty:  0.00506163
Score:  0.953
Data Source:  STRINGDB
UCKL1
Tbio
Family:  Kinase
Novelty:  0.18522799
Score:  0.948
Data Source:  STRINGDB
DPYD
Tclin
Family:  Enzyme
Novelty:  0.00207216
Score:  0.948
Data Source:  STRINGDB
UMPS
Tclin
Family:  Enzyme
Novelty:  0.00848756
Score:  0.945
Data Source:  STRINGDB
TK1
Tchem
Family:  Kinase
Novelty:  0.00139343
Score:  0.937
Data Source:  STRINGDB
TK2
Tchem
Family:  Kinase
Novelty:  0.10642442
Score:  0.932
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (16)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Nucleotide salvage
Reactome
Pyrimidine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Nucleotide salvage
Pyrimidine catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
uridine phosphorylase 2
698067
Mouse
MGI:1923904
76654
Rat
RGD:1308188
295620
Cow
uridine phosphorylase 2
VGNC:36689
534937
Opossum
uridine phosphorylase 2
100021464
Species
Name
OMA
EggNOG
Inparanoid
Macaque
uridine phosphorylase 2
Mouse
Rat
Cow
uridine phosphorylase 2
Opossum
uridine phosphorylase 2
Publication Statistics
PubMed Score 24.76
PubMed score by year
PubTator Score 5.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title