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Tbio
UPK3B
Uroplakin-3b

Protein Summary
Description
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257632
  • ENSP00000257632
  • ENSG00000243566
  • ENST00000334348
  • ENSP00000334938
  • ENST00000394849
  • ENSP00000378319
  • ENST00000448265
  • ENSP00000441284
  • ENSG00000276184
  • ENST00000615976
  • ENSP00000479568

Symbol
  • P35
  • UP3B
  • UPIIIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
PubMedID
0.61
transcription factor
0.6
cellular component
0.58
cell line
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.44   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.44   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
MYO18A
Tbio
Novelty:  0.05058328
p_int:  0.996482603
p_ni:  0.003517397
Score:  0.269
Data Source:  BioPlex,STRINGDB
UPK1B
Tbio
Novelty:  0.0285906
Score:  0.973
Data Source:  STRINGDB
UPK2
Tbio
Novelty:  0.01066132
Score:  0.807
Data Source:  STRINGDB
UPK1A
Tbio
Novelty:  0.01748122
Score:  0.803
Data Source:  STRINGDB
UPK3A
Tbio
Novelty:  0.00840631
Score:  0.781
Data Source:  STRINGDB
PTPRB
Tchem
Family:  Enzyme
Novelty:  0.00797419
Score:  0.58
Data Source:  STRINGDB
FAM180A
Tdark
Novelty:  2.46799861
Score:  0.575
Data Source:  STRINGDB
PTPRS
Tchem
Family:  Enzyme
Novelty:  0.00587115
Score:  0.554
Data Source:  STRINGDB
CLDN8
Tbio
Novelty:  0.02218455
Score:  0.53
Data Source:  STRINGDB
LRRN4
Tdark
Novelty:  0.27448639
Score:  0.514
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uroplakin 3B
100611882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uroplakin 3B
Publication Statistics
PubMed Score 6.44
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title