Protein Summary
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity). This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]
- ENST00000264031
- ENSP00000264031
- ENSG00000110375
- UP2
- UPII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.89 | ||
cell type or tissue | 0.7 | ||
cellular component | 0.61 | ||
transcription factor | 0.5 | ||
tissue | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 102.43 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 80 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 102.43 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 80 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (60)
ALCAM
Novelty: 0.00244371
p_int: 0.999930612
p_ni: 0.000069252
p_wrong: 1.35e-7
Data Source: BioPlex
PCDHGA11
Novelty: 0.44130091
p_int: 0.999886655
p_ni: 0.000112145
p_wrong: 0.0000012
Data Source: BioPlex
IL6ST
Novelty: 0.01026472
p_int: 0.999698426
p_ni: 0.000079661
p_wrong: 0.000221913
Data Source: BioPlex
BCAM
Novelty: 0.01697541
p_int: 0.997637444
p_ni: 0.002350396
p_wrong: 0.00001216
Data Source: BioPlex
ABHD17B
Family: Enzyme
Novelty: 0.64360453
p_int: 0.995489729
p_ni: 0.00432706
p_wrong: 0.000183211
Data Source: BioPlex
TMEM67
Novelty: 0.02573267
p_int: 0.988783793
p_ni: 0.011212011
p_wrong: 0.000004196
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (5)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 4 | 0 | 1.1 | 91.4 | |||||
primary biliary cirrhosis | 3 | 3 | 0 | 1.4 | 70.5 | ||||
3 | 2 | 2 | 1.1 | 69.7 | |||||
serum albumin measurement | 1 | 1 | 1 | 62.1 | |||||
age at onset | 2 | 2 | 1 | 1.1 | 53.6 | ||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 91.4 | |||||
primary biliary cirrhosis | 0 | 1.4 | 70.5 | ||||
2 | 1.1 | 69.7 | |||||
serum albumin measurement | 1 | 62.1 | |||||
age at onset | 1 | 1.1 | 53.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | uroplakin 2 | VGNC:952 | 101057577 | |||||
Mouse | MGI:98913 | 22269 | ||||||
Rat | RGD:1597393 | 689093 | ||||||
Dog | uroplakin 2 | VGNC:48156 | 610673 | |||||
Horse | uroplakin 2 | VGNC:24810 | 100063180 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | uroplakin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | uroplakin 2 | |||||
Horse | uroplakin 2 | |||||
Publication Statistics
PubMed Score 102.43
PubMed score by year
PubTator Score 103.20
PubTator score by year
Related Publications
Text Mined References (26)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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