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Tbio
UPK2
Uroplakin-2

Protein Summary
Description
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity). This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264031
  • ENSP00000264031
  • ENSG00000110375

Symbol
  • UP2
  • UPII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.89
cell type or tissue
0.7
cellular component
0.61
transcription factor
0.5
tissue
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.43   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.43   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
ALCAM
Tbio
Novelty:  0.00244371
p_int:  0.999930612
p_ni:  0.000069252
p_wrong:  1.35e-7
Data Source:  BioPlex
NRP2
Tbio
Novelty:  0.00764179
p_int:  0.999899229
p_ni:  0.000100771
Data Source:  BioPlex
PCDHGA11
Tdark
Novelty:  0.44130091
p_int:  0.999886655
p_ni:  0.000112145
p_wrong:  0.0000012
Data Source:  BioPlex
IL6ST
Tclin
Novelty:  0.01026472
p_int:  0.999698426
p_ni:  0.000079661
p_wrong:  0.000221913
Data Source:  BioPlex
BCAM
Tbio
Novelty:  0.01697541
p_int:  0.997637444
p_ni:  0.002350396
p_wrong:  0.00001216
Data Source:  BioPlex
ABHD17B
Tbio
Family:  Enzyme
Novelty:  0.64360453
p_int:  0.995489729
p_ni:  0.00432706
p_wrong:  0.000183211
Data Source:  BioPlex
TMEM67
Tbio
Novelty:  0.02573267
p_int:  0.988783793
p_ni:  0.011212011
p_wrong:  0.000004196
Data Source:  BioPlex
INTS4
Tdark
Novelty:  0.20868831
p_int:  0.987633996
p_ni:  0.012366004
Data Source:  BioPlex
PCDH9
Tbio
Novelty:  0.03928208
p_int:  0.98524398
p_ni:  0.01475602
Data Source:  BioPlex
CELSR2
Tbio
Family:  GPCR
Novelty:  0.02657319
p_int:  0.98354445
p_ni:  0.01645555
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
4
0
1.1
91.4
primary biliary cirrhosis
3
3
0
1.4
70.5
3
2
2
1.1
69.7
serum albumin measurement
1
1
1
62.1
age at onset
2
2
1
1.1
53.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
91.4
primary biliary cirrhosis
0
1.4
70.5
2
1.1
69.7
serum albumin measurement
1
62.1
age at onset
1
1.1
53.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uroplakin 2
VGNC:952
101057577
Mouse
MGI:98913
22269
Rat
RGD:1597393
689093
Dog
uroplakin 2
VGNC:48156
610673
Horse
uroplakin 2
VGNC:24810
100063180
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uroplakin 2
Mouse
Rat
Dog
uroplakin 2
Horse
uroplakin 2
Publication Statistics
PubMed Score 102.43
PubMed score by year
PubTator Score 103.20
PubTator score by year
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Related Publications
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PMID
Year
Title