Tbio UPK1A Uroplakin-1a

Protein Summary

Description

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity). The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• O00322
• Q3KNU5
• Q3KNU6
• UP1a

Gene Name

• UPK1A

Ensembl ID

• ENST00000222275
• ENSP00000222275
• ENSG00000105668
• ENST00000379013
• ENSP00000368298
• ENST00000616789
• ENSP00000478942
• ENST00000617999
• ENSP00000483176

Symbol

• TSPAN21
• UP1A
• UPIA
• UPKA
• TSPAN21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.63
cell type or tissue	0.6
cellular component	0.59
disease perturbation	0.43
protein domain	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.81   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.81   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (99)

Explore Interacting Targets

1 – 10 of 99

• See Interactions on String-DB

TMEM62

Tdark

Novelty:  1.79070108

p_int:  0.999979759

p_ni:  0.000019809

p_wrong:  4.32e-7

Score:  0.188

Data Source:  BioPlex,STRINGDB

SLC44A1

Tbio

Family:  Transporter

Novelty:  0.01499456

p_int:  0.999976264

p_ni:  0.000023686

p_wrong:  5.1e-8

Data Source:  BioPlex

TUSC3

Tbio

Novelty:  0.01388722

p_int:  0.9999095

p_ni:  0.000090239

p_wrong:  2.6e-7

Data Source:  BioPlex

FZD7

Tchem

Family:  GPCR

Novelty:  0.00916448

p_int:  0.999862023

p_ni:  0.000136311

p_wrong:  0.000001666

Data Source:  BioPlex

FZD3

Tbio

Family:  GPCR

Novelty:  0.00964507

p_int:  0.999788027

p_ni:  0.000055802

p_wrong:  0.000156171

Data Source:  BioPlex

FZD2

Tbio

Family:  GPCR

Novelty:  0.00774893

p_int:  0.999777299

p_ni:  0.000199697

p_wrong:  0.000023004

Data Source:  BioPlex

FZD8

Tbio

Family:  GPCR

Novelty:  0.01613553

p_int:  0.999753992

p_ni:  0.00020702

p_wrong:  0.000038988

Score:  0.181

Data Source:  BioPlex,STRINGDB

CIB1

Tbio

Novelty:  0.00364869

p_int:  0.999689132

p_ni:  0.000004958

p_wrong:  0.00030591

Score:  0.177

Data Source:  BioPlex,STRINGDB

DPY19L4

Tdark

Family:  Enzyme

Novelty:  0.99997412

p_int:  0.999622689

p_ni:  0.00037656

p_wrong:  7.51e-7

Data Source:  BioPlex

DPY19L1

Tdark

Family:  Enzyme

Novelty:  0.34765717

p_int:  0.999385121

p_ni:  0.000614852

p_wrong:  2.7e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (1)

Components (7)

Processes (3)

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GO Term	Evidence	Assigned by
protein homodimerization activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	1	1	1		64.9
self reported educational attainment	EFO_0004784	1	1	1		46.1
mathematical ability	EFO_0004875	1	1	1		38.8
eosinophil percentage of leukocytes	EFO_0007991	1	1	1		37.6
age at first sexual intercourse measurement	EFO_0009749	1	1	1		33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	1		64.9
self reported educational attainment	EFO_0004784	1		46.1
mathematical ability	EFO_0004875	1		38.8
eosinophil percentage of leukocytes	EFO_0007991	1		37.6
age at first sexual intercourse measurement	EFO_0009749	1		33.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
age at first sexual intercourse measurement
eosinophil percentage of leukocytes
mathematical ability
red blood cell distribution width
self reported educational attainment

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	uroplakin 1A		747975
Macaque	uroplakin 1A		710131
Mouse	uroplakin 1A	MGI:98911	109637
Dog	uroplakin 1A	VGNC:48154	484579
Horse	uroplakin 1A	VGNC:24808	100051323

Species	Name	OMA	EggNOG	Inparanoid
Chimp	uroplakin 1A
Macaque	uroplakin 1A
Mouse	uroplakin 1A
Dog	uroplakin 1A
Horse	uroplakin 1A

Publication Statistics

PubMed Score 56.81

PubMed score by year

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PubTator Score 23.83

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (9)

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10

0 of 0

PMID	Year	Title