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Tbio
UPK1A
Uroplakin-1a

Protein Summary
Description
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity). The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of supe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222275
  • ENSP00000222275
  • ENSG00000105668
  • ENST00000379013
  • ENSP00000368298
  • ENST00000616789
  • ENSP00000478942
  • ENST00000617999
  • ENSP00000483176

Symbol
  • TSPAN21
  • UP1A
  • UPIA
  • UPKA
  • TSPAN21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.63
cell type or tissue
0.6
cellular component
0.59
disease perturbation
0.43
protein domain
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.81   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.81   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
TMEM62
Tdark
Novelty:  1.79070108
p_int:  0.999979759
p_ni:  0.000019809
p_wrong:  4.32e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
SLC44A1
Tbio
Family:  Transporter
Novelty:  0.01499456
p_int:  0.999976264
p_ni:  0.000023686
p_wrong:  5.1e-8
Data Source:  BioPlex
TUSC3
Tbio
Novelty:  0.01388722
p_int:  0.9999095
p_ni:  0.000090239
p_wrong:  2.6e-7
Data Source:  BioPlex
FZD7
Tchem
Family:  GPCR
Novelty:  0.00916448
p_int:  0.999862023
p_ni:  0.000136311
p_wrong:  0.000001666
Data Source:  BioPlex
FZD3
Tbio
Family:  GPCR
Novelty:  0.00964507
p_int:  0.999788027
p_ni:  0.000055802
p_wrong:  0.000156171
Data Source:  BioPlex
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
p_int:  0.999777299
p_ni:  0.000199697
p_wrong:  0.000023004
Data Source:  BioPlex
FZD8
Tbio
Family:  GPCR
Novelty:  0.01613553
p_int:  0.999753992
p_ni:  0.00020702
p_wrong:  0.000038988
Score:  0.181
Data Source:  BioPlex,STRINGDB
CIB1
Tbio
Novelty:  0.00364869
p_int:  0.999689132
p_ni:  0.000004958
p_wrong:  0.00030591
Score:  0.177
Data Source:  BioPlex,STRINGDB
DPY19L4
Tdark
Family:  Enzyme
Novelty:  0.99997412
p_int:  0.999622689
p_ni:  0.00037656
p_wrong:  7.51e-7
Data Source:  BioPlex
DPY19L1
Tdark
Family:  Enzyme
Novelty:  0.34765717
p_int:  0.999385121
p_ni:  0.000614852
p_wrong:  2.7e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
64.9
self reported educational attainment
1
1
1
46.1
mathematical ability
1
1
1
38.8
eosinophil percentage of leukocytes
1
1
1
37.6
age at first sexual intercourse measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
64.9
self reported educational attainment
1
46.1
mathematical ability
1
38.8
eosinophil percentage of leukocytes
1
37.6
age at first sexual intercourse measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uroplakin 1A
747975
Macaque
uroplakin 1A
710131
Mouse
MGI:98911
109637
Dog
uroplakin 1A
VGNC:48154
484579
Horse
uroplakin 1A
VGNC:24808
100051323
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uroplakin 1A
Macaque
uroplakin 1A
Mouse
Dog
uroplakin 1A
Horse
uroplakin 1A
Publication Statistics
PubMed Score 56.81
PubMed score by year
PubTator Score 23.83
PubTator score by year
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Related Publications
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PMID
Year
Title