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Tbio
UPF1
Regulator of nonsense transcripts 1

Protein Summary
Description
RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262803
  • ENSP00000262803
  • ENSG00000005007
  • ENST00000599848
  • ENSP00000470142

Symbol
  • KIAA0221
  • RENT1
  • HUPF1
  • NORF1
  • RENT1
  • smg-2
  • pNORF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
kinase perturbation
0.91
tissue
0.71
transcription factor binding site profile
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.11   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.11   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (377)
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.99493637
p_ni:  0.00506363
Data Source:  BioPlex
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.988516057
p_ni:  0.011483943
Data Source:  BioPlex
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.98834221
p_ni:  0.01165779
Score:  0.19
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.98819897
p_ni:  0.01180103
Score:  0.397
Data Source:  BioPlex,STRINGDB
ILF2
Tbio
Novelty:  0.01598188
p_int:  0.983540391
p_ni:  0.016459609
Score:  0.418
Data Source:  BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.982700396
p_ni:  0.017299604
Data Source:  BioPlex
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.979454985
p_ni:  0.020545015
Score:  0.165
Data Source:  BioPlex,STRINGDB
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.976788733
p_ni:  0.023211267
Score:  0.334
Data Source:  BioPlex,STRINGDB
ZC3H3
Tbio
Novelty:  0.26894046
p_int:  0.975312478
p_ni:  0.024687522
Score:  0.192
Data Source:  BioPlex,STRINGDB
MEMO1
Tbio
Novelty:  0.0506558
p_int:  0.973421749
p_ni:  0.026578251
Score:  0.184
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Reactome
Nonsense-Mediated Decay (NMD)
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
38.1
low density lipoprotein cholesterol measurement
1
1
1
34.9
apolipoprotein B measurement
1
1
1
32.7
glomerular filtration rate
1
1
1
29
triglyceride measurement
1
1
1
15.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
38.1
low density lipoprotein cholesterol measurement
1
34.9
apolipoprotein B measurement
1
32.7
glomerular filtration rate
1
29
triglyceride measurement
1
15.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UPF1, RNA helicase and ATPase
VGNC:8692
456373
Macaque
UPF1, RNA helicase and ATPase
720288
Mouse
MGI:107995
19704
Rat
RGD:1589127
684558
Dog
UPF1, RNA helicase and ATPase
VGNC:48150
476664
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UPF1, RNA helicase and ATPase
Macaque
UPF1, RNA helicase and ATPase
Mouse
Rat
Dog
UPF1, RNA helicase and ATPase
Publication Statistics
PubMed Score 389.11
PubMed score by year
PubTator Score 155.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title