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Tbio
UNCX
Homeobox protein unc-4 homolog

Protein Summary
Description
Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity). This gene encodes a homeobox transcription factor that is involved in somitogenesis and neurogenesis and is required for the maintenance and differentiation of specific elements of the axial skeleton. This gene also plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and deliver hormones that control peripheral functions. The expression of this gene is associated with an increased frequency of acute myeloid leukemia. [provided by RefSeq, J ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316333
  • ENSP00000314480
  • ENSG00000164853

Symbol
  • UNCX4.1
  • UNCX4.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.59
gene perturbation
0.59
biological process
0.54
PubMedID
0.54
virus perturbation
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
MESP2
Tbio
Family:  TF
Novelty:  0.02601024
Score:  0.717
Data Source:  STRINGDB
LFNG
Tbio
Family:  Enzyme
Novelty:  0.02660238
Score:  0.66
Data Source:  STRINGDB
PAX1
Tbio
Family:  TF
Novelty:  0.00618274
Score:  0.642
Data Source:  STRINGDB
TBX18
Tbio
Family:  TF
Novelty:  0.01287164
Score:  0.637
Data Source:  STRINGDB
HES7
Tbio
Family:  TF
Novelty:  0.02014919
Score:  0.635
Data Source:  STRINGDB
MSGN1
Tbio
Family:  TF
Novelty:  0.10117512
Score:  0.627
Data Source:  STRINGDB
RIPPLY2
Tdark
Novelty:  0.16163153
Score:  0.596
Data Source:  STRINGDB
TBX6
Tbio
Family:  TF
Novelty:  0.01060902
Score:  0.582
Data Source:  STRINGDB
BARHL2
Tbio
Family:  TF
Novelty:  0.09447868
Score:  0.574
Data Source:  STRINGDB
PAX9
Tbio
Family:  TF
Novelty:  0.00581813
Score:  0.564
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
6
11
13.8
98.4
blood urea nitrogen measurement
4
4
4
96.4
creatinine measurement
4
5
6
95.6
hematocrit
5
3
5
94.2
hemoglobin measurement
5
3
5
93.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
11
13.8
98.4
blood urea nitrogen measurement
4
96.4
creatinine measurement
6
95.6
hematocrit
5
94.2
hemoglobin measurement
5
93.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:108013
22255
Rat
RGD:69361
29375
Dog
UNC homeobox
VGNC:48146
491604
Cow
UNC homeobox [Source:HGNC Symbol;Acc:HGNC:33194]
Xenopus
UNC homeobox
XB-GENE-920201
100492016
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
UNC homeobox
Cow
UNC homeobox [Source:HGNC Symbol;Acc:HGNC:33194]
Xenopus
UNC homeobox
Publication Statistics
PubMed Score 17.92
PubMed score by year
PubTator Score 1.13
PubTator score by year
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Related Publications
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PMID
Year
Title