You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UNC5CL
UNC5C-like protein

Protein Summary
Description
Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244565
  • ENSP00000244565
  • ENSG00000124602
  • ENST00000373164
  • ENSP00000362258

Symbol
  • ZUD
  • ZUD
  • MUXA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
tissue sample
0.65
cell line
0.53
PubMedID
0.49
transcription factor
0.46


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.01   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.01   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
BICD2
Tbio
Novelty:  0.01725046
p_int:  0.999980346
p_ni:  0.000019654
Score:  0.213
Data Source:  BioPlex,STRINGDB
INSR
Tclin
Family:  Kinase
Novelty:  0.00230617
p_int:  0.999877875
p_ni:  0.000122125
Score:  0.188
Data Source:  BioPlex,STRINGDB
NUMB
Tbio
Novelty:  0.00211228
p_int:  0.999019936
p_ni:  0.000980037
p_wrong:  2.7e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
LRRC41
Tbio
Novelty:  0.12601472
p_int:  0.997394021
p_ni:  0.002605979
Score:  0.189
Data Source:  BioPlex,STRINGDB
KDM8
Tbio
Family:  Epigenetic
Novelty:  0.03368031
p_int:  0.995051101
p_ni:  0.000579252
p_wrong:  0.004369648
Score:  0.253
Data Source:  BioPlex,STRINGDB
IGF1R
Tclin
Family:  Kinase
Novelty:  0.00034532
p_int:  0.989072607
p_ni:  0.010927393
Score:  0.23
Data Source:  BioPlex,STRINGDB
NUMBL
Tbio
Novelty:  0.01383607
p_int:  0.978080304
p_ni:  0.000001337
p_wrong:  0.021918359
Score:  0.206
Data Source:  BioPlex,STRINGDB
FLVCR1
Tbio
Novelty:  0.02110276
p_int:  0.954309692
p_ni:  0.045690308
Data Source:  BioPlex
CHORDC1
Tbio
Novelty:  0.03400277
p_int:  0.940295685
p_ni:  0.059704228
p_wrong:  8.7e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
USP22
Tbio
Family:  Enzyme
Novelty:  0.01416662
p_int:  0.89348737
p_ni:  0.105392513
p_wrong:  0.001120117
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-C motif chemokine 20 measurement
1
1
1
68.8
late-onset Alzheimers disease
1
1
0
1.3
58.4
mean corpuscular volume
1
1
1
58.4
urate measurement
1
1
1
44.2
leukocyte count
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-C motif chemokine 20 measurement
1
68.8
late-onset Alzheimers disease
0
1.3
58.4
mean corpuscular volume
1
58.4
urate measurement
1
44.2
leukocyte count
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
unc-5 family C-terminal like
VGNC:3783
462673
Macaque
unc-5 family C-terminal like
719655
Mouse
MGI:1923839
76589
Rat
RGD:1587368
301225
Dog
unc-5 family C-terminal like
VGNC:48142
481786
Species
Name
OMA
EggNOG
Inparanoid
Chimp
unc-5 family C-terminal like
Macaque
unc-5 family C-terminal like
Mouse
Rat
Dog
unc-5 family C-terminal like
Publication Statistics
PubMed Score 9.01
PubMed score by year
PubTator Score 3.51
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title