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Tbio
UNC5A
Netrin receptor UNC5A

Protein Summary
Description
Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329542
  • ENSP00000332737
  • ENSG00000113763

Symbol
  • KIAA1976
  • UNC5H1
  • UNC5H1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
tissue sample
0.75
gene perturbation
0.74
transcription factor
0.5
transcription factor perturbation
0.47


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.7   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.7   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
NTN1
Tbio
Novelty:  0.00183678
Score:  0.995
Data Source:  Reactome,STRINGDB
MAGED1
Tbio
Novelty:  0.02143963
Score:  0.976
Data Source:  Reactome,STRINGDB
DCC
Tbio
Novelty:  0.01273911
Score:  0.976
Data Source:  Reactome,STRINGDB
NTN4
Tbio
Novelty:  0.03056042
Score:  0.972
Data Source:  Reactome,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.918
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.913
Data Source:  Reactome,STRINGDB
UNC5D
Tbio
Novelty:  0.06891857
Score:  0.91
Data Source:  STRINGDB
NEO1
Tbio
Novelty:  0.00625858
Score:  0.909
Data Source:  STRINGDB
APPL1
Tbio
Novelty:  0.00973424
Score:  0.908
Data Source:  STRINGDB
UNC5B
Tbio
Novelty:  0.01474065
Score:  0.908
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Axon guidance
Reactome
Caspase activation via Dependence Receptors in the absence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Apoptosis
Axon guidance
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Developmental Biology
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
1
2
81
age at menarche
1
1
1
56
self reported educational attainment
1
1
1
38.2
1
1
0
1.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
81
age at menarche
1
56
self reported educational attainment
1
38.2
0
1.1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
unc-5 netrin receptor A
VGNC:4220
462297
Macaque
unc-5 netrin receptor A
705285
Mouse
MGI:894682
107448
Rat
RGD:621755
60629
Dog
unc-5 netrin receptor A
VGNC:48139
489097
Species
Name
OMA
EggNOG
Inparanoid
Chimp
unc-5 netrin receptor A
Macaque
unc-5 netrin receptor A
Mouse
Rat
Dog
unc-5 netrin receptor A
Publication Statistics
PubMed Score 19.70
PubMed score by year
PubTator Score 8.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title