You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
UNC13C
Protein unc-13 homolog C

Protein Summary
Description
May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260323
  • ENSP00000260323
  • ENSG00000137766
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
protein domain
0.97
metabolite
0.82
cell line
0.68
phenotype
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.82   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.82   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
UNC13A
Tbio
Novelty:  0.01009835
Score:  0.961
Data Source:  STRINGDB
UNC13B
Tbio
Novelty:  0.00429808
Score:  0.959
Data Source:  STRINGDB
RIMS1
Tbio
Novelty:  0.01126545
Score:  0.693
Data Source:  STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.682
Data Source:  STRINGDB
STXBP1
Tbio
Novelty:  0.00339098
Score:  0.669
Data Source:  STRINGDB
CALM3
Tclin
Novelty:  0.00461552
Score:  0.668
Data Source:  STRINGDB
CALM2
Tclin
Novelty:  0.01876254
Score:  0.664
Data Source:  STRINGDB
COL4A1
Tbio
Novelty:  0.00358049
Score:  0.649
Data Source:  STRINGDB
P0DI83
Tbio
Novelty:  0.03645677
Score:  0.647
Data Source:  STRINGDB
Q9BZG1
Tbio
Family:  Enzyme
Novelty:  0.03645677
Score:  0.647
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial heteroplasmy measurement
1
1
1
9.6
smoking initiation
1
1
1
0.7
waist circumference
1
1
1
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial heteroplasmy measurement
1
9.6
smoking initiation
1
0.7
waist circumference
1
0.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
unc-13 homolog C
453453
Macaque
unc-13 homolog C
697368
Mouse
MGI:2149021
208898
Rat
RGD:628592
286931
Dog
unc-13 homolog C
VGNC:48135
487564
Species
Name
OMA
EggNOG
Inparanoid
Chimp
unc-13 homolog C
Macaque
unc-13 homolog C
Mouse
Rat
Dog
unc-13 homolog C
Publication Statistics
PubMed Score 10.82
PubMed score by year
PubTator Score 3.89
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title