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Tbio
UNC13B
Protein unc-13 homolog B

Protein Summary
Description
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378495
  • ENSP00000367756
  • ENSG00000198722
  • ENST00000619578
  • ENSP00000479261

Symbol
  • UNC13
  • UNC13
  • MUNC13
  • Unc13h2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
protein domain
0.92
metabolite
0.82
biological process
0.77
cellular component
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.14   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.14   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.999999927
p_ni:  7.2e-8
Score:  0.321
Data Source:  BioPlex,STRINGDB
CCDC40
Tbio
Novelty:  0.06726469
p_int:  0.999999898
p_ni:  8.6e-8
p_wrong:  1.6e-8
Score:  0.199
Data Source:  BioPlex,STRINGDB
DIRAS2
Tbio
Family:  Enzyme
Novelty:  0.12334631
p_int:  0.999997951
p_ni:  0.000002041
p_wrong:  8e-9
Score:  0.373
Data Source:  BioPlex,STRINGDB
RIMS1
Tbio
Novelty:  0.01126545
Score:  0.997
Data Source:  Reactome,STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.988
Data Source:  STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.984
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.982
Data Source:  STRINGDB
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
Score:  0.979
Data Source:  STRINGDB
VAMP2
Tbio
Novelty:  0.00187736
Score:  0.978
Data Source:  STRINGDB
PPFIA3
Tbio
Novelty:  0.03837299
Score:  0.977
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Non-traceable Author Statement (NAS)
ParkinsonsUK-UCL
Non-traceable Author Statement (NAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
57.8
mean platelet volume
1
1
1
53.7
mean corpuscular volume
1
1
1
33
mean reticulocyte volume
1
1
1
29.8
mean corpuscular hemoglobin concentration
1
1
1
12.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
57.8
mean platelet volume
1
53.7
mean corpuscular volume
1
33
mean reticulocyte volume
1
29.8
mean corpuscular hemoglobin concentration
1
12.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 227.14
PubMed score by year
PubTator Score 77.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title