UNC13B
Protein unc-13 homolog B
Protein Summary
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocy ...more
- ENST00000378495
- ENSP00000367756
- ENSG00000198722
- ENST00000619578
- ENSP00000479261
- UNC13
- UNC13
- MUNC13
- Unc13h2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.95 | ||
protein domain | 0.92 | ||
metabolite | 0.82 | ||
biological process | 0.77 | ||
cellular component | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.14 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 174 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.14 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 174 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (125)
CALML3
Novelty: 0.0336689
p_int: 0.999999927
p_ni: 7.2e-8
Score: 0.321
Data Source: BioPlex,STRINGDB
CCDC40
Novelty: 0.06726469
p_int: 0.999999898
p_ni: 8.6e-8
p_wrong: 1.6e-8
Score: 0.199
Data Source: BioPlex,STRINGDB
DIRAS2
Family: Enzyme
Novelty: 0.12334631
p_int: 0.999997951
p_ni: 0.000002041
p_wrong: 8e-9
Score: 0.373
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (14)
Reactome (8)
KEGG (1)
PathwayCommons (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acetylcholine Neurotransmitter Release Cycle | ||||
Reactome | Dopamine Neurotransmitter Release Cycle | ||||
Reactome | Glutamate Neurotransmitter Release Cycle | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter release cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acetylcholine Neurotransmitter Release Cycle | ||||
Dopamine Neurotransmitter Release Cycle | ||||
Glutamate Neurotransmitter Release Cycle | ||||
Neuronal System | ||||
Neurotransmitter release cycle | ||||
Viral Interactions (0)
Gene Ontology Terms (42)
Functions (7)
Components (16)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | ParkinsonsUK-UCL | |||
Non-traceable Author Statement (NAS) | ParkinsonsUK-UCL | |||
Non-traceable Author Statement (NAS) | ParkinsonsUK-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 1 | 1 | 1 | 57.8 | |||||
mean platelet volume | 1 | 1 | 1 | 53.7 | |||||
mean corpuscular volume | 1 | 1 | 1 | 33 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 29.8 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 12.3 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 1 | 57.8 | |||||
mean platelet volume | 1 | 53.7 | |||||
mean corpuscular volume | 1 | 33 | |||||
mean reticulocyte volume | 1 | 29.8 | |||||
mean corpuscular hemoglobin concentration | 1 | 12.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | unc-13 homolog B | 697393 | ||||||
Mouse | MGI:1342278 | 22249 | ||||||
Rat | RGD:619723 | 64830 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | unc-13 homolog B | |||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 227.14
PubMed score by year
PubTator Score 77.27
PubTator score by year
Related Publications
Text Mined References (28)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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