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Tbio
UNC13A
Protein unc-13 homolog A

Protein Summary
Description
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000519716
  • ENSP00000429562
  • ENSG00000130477

Symbol
  • KIAA1032
  • Munc13-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
metabolite
0.82
transcription factor binding site profile
0.66
biological process
0.61
phenotype
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.76   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.76   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
UNC13C
Tdark
Novelty:  0.08194531
Score:  0.961
Data Source:  STRINGDB
UNC13B
Tbio
Novelty:  0.00429808
Score:  0.958
Data Source:  STRINGDB
BSN
Tbio
Novelty:  0.00468806
Score:  0.91
Data Source:  STRINGDB
RIMS1
Tbio
Novelty:  0.01126545
Score:  0.907
Data Source:  STRINGDB
STXBP1
Tbio
Novelty:  0.00339098
Score:  0.858
Data Source:  STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.831
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.83
Data Source:  STRINGDB
RIMS2
Tbio
Novelty:  0.02785894
Score:  0.804
Data Source:  STRINGDB
STX1A
Tbio
Novelty:  0.00087207
Score:  0.799
Data Source:  STRINGDB
CADPS
Tbio
Novelty:  0.01737775
Score:  0.775
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
86.1
serum gamma-glutamyl transferase measurement
1
1
1
83.1
4
3
4
76.7
5
2
0
1.2
75.4
basophil count
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
86.1
serum gamma-glutamyl transferase measurement
1
83.1
4
76.7
0
1.2
75.4
basophil count
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3051532
382018
Rat
RGD:619722
64829
Cow
unc-13 homolog A
VGNC:36664
526874
Zebrafish
ZDB-GENE-050208-748
568618
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
unc-13 homolog A
Zebrafish
Publication Statistics
PubMed Score 106.76
PubMed score by year
PubTator Score 45.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title