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Tchem
ULK3
Serine/threonine-protein kinase ULK3

Protein Summary
Description
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000440863
  • ENSP00000400312
  • ENSG00000140474
  • ENST00000568667
  • ENSP00000457853
  • ENST00000569437
  • ENSP00000456051
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
molecular function
0.91
drug perturbation
0.87
protein domain
0.85
small molecule
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.22   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 347   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.22   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 347   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (71)
BCAN
Tbio
Novelty:  0.00737982
p_int:  0.99997977
p_ni:  3.5e-8
p_wrong:  0.000020195
Score:  0.622
Data Source:  BioPlex,STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.988143104
p_ni:  0.011856896
Score:  0.189
Data Source:  BioPlex,STRINGDB
AIP
Tbio
Novelty:  0.00869592
p_int:  0.750682944
p_ni:  0.249317056
Score:  0.534
Data Source:  BioPlex,STRINGDB
GLI1
Tchem
Family:  TF
Novelty:  0.00077281
Score:  0.989
Data Source:  Reactome,STRINGDB
GLI2
Tchem
Family:  TF
Novelty:  0.00229126
Score:  0.972
Data Source:  Reactome,STRINGDB
IST1
Tbio
Novelty:  0.01780503
Score:  0.971
Data Source:  STRINGDB
GLI3
Tbio
Family:  TF
Novelty:  0.00051217
Score:  0.951
Data Source:  Reactome,STRINGDB
SUFU
Tbio
Novelty:  0.00475249
Score:  0.928
Data Source:  Reactome,STRINGDB
ATG101
Tbio
Novelty:  0.03407206
Score:  0.815
Data Source:  STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
Score:  0.809
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Hedgehog 'on' state (R-HSA-5632684)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hedgehog 'on' state
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
Hedgehog 'on' state
Signal Transduction
Signaling by Hedgehog
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
5
3
5
89.6
neutrophil percentage of leukocytes
2
2
2
81.6
red blood cell density measurement
1
1
1
80
monocyte count
2
2
2
78.9
monocyte percentage of leukocytes
1
1
1
78.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
5
89.6
neutrophil percentage of leukocytes
2
81.6
red blood cell density measurement
1
80
monocyte count
2
78.9
monocyte percentage of leukocytes
1
78.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
unc-51 like kinase 3
VGNC:2465
453747
Mouse
MGI:1918992
71742
Rat
RGD:1587417
691171
Dog
unc-51 like kinase 3
VGNC:48130
487651
Horse
unc-51 like kinase 3
VGNC:24786
100062139
Species
Name
OMA
EggNOG
Inparanoid
Chimp
unc-51 like kinase 3
Mouse
Rat
Dog
unc-51 like kinase 3
Horse
unc-51 like kinase 3
Publication Statistics
PubMed Score 14.22
PubMed score by year
PubTator Score 8.48
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title