Tchem ULK1 Serine/threonine-protein kinase ULK1

Protein Summary

Description

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).

Uniprot Accession IDs

• O75385
• Q9UQ28

Gene Name

• ULK1

Ensembl ID

• ENST00000321867
• ENSP00000324560
• ENSG00000177169

Symbol

• KIAA0722
• ATG1
• ATG1A
• UNC51
• hATG1
• Unc51.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
biological process	0.92
protein domain	0.92
cellular component	0.86
small molecule	0.85

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Serine/threonine-protein Kinase Ulk1

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Ulk Family / Serine/threonine-protein Kinase Ulk1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.15   (req: < 5)

Gene RIFs: 190   (req: <= 3)

Antibodies: 796   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.15   (req: >= 5)

Gene RIFs: 190   (req: > 3)

Antibodies: 796   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2