You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ULBP3
UL16-binding protein 3

Protein Summary
Description
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367339
  • ENSP00000356308
  • ENSG00000131019
  • ENST00000438272
  • ENSP00000403562

Symbol
  • N2DL3
  • RAET1N
  • N2DL-3
  • RAET1N
  • NKG2DL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.68
tissue sample
0.56
cell line
0.48
disease
0.47
tissue
0.46


Protein Classes
 No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.42   (req: < 5)
View Publications
Gene RIFs: 16   (req: <= 3)
View Gene RIFs
Antibodies: 127   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.42   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
 No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
Go To Tool
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
Go To Tool
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
Go To Tool
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Go To Tool
Approved Drugs (0)
 No approved drugs found
Active Ligands (0)
 No active ligands found
Protein-Protein Interactions (54)
1 – 10 of 54
ULBP1
Tbio
Novelty:  0.01603533
p_int:  0.999999796
p_ni:  3.1e-8
p_wrong:  1.73e-7
Score:  0.938
Data Source:  BioPlex,STRINGDB
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.99984493
p_ni:  0.000147463
p_wrong:  0.000007608
Data Source:  BioPlex
TNFSF8
Tbio
Novelty:  0.01292216
p_int:  0.998803442
p_ni:  0.001196557
p_wrong:  1e-9
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.99704057
p_ni:  0.002952425
p_wrong:  0.000007006
Data Source:  BioPlex
IL27RA
Tbio
Novelty:  0.01348051
p_int:  0.995591319
p_ni:  0.004408615
p_wrong:  6.7e-8
Data Source:  BioPlex
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.994698339
p_ni:  0.005301572
p_wrong:  8.8e-8
Data Source:  BioPlex
CEACAM21
Tdark
Novelty:  0.46116153
p_int:  0.994684332
p_ni:  0.005315529
p_wrong:  1.4e-7
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.994395996
p_ni:  0.005602288
p_wrong:  0.000001717
Score:  0.18
Data Source:  BioPlex,STRINGDB
RAET1E
Tbio
Novelty:  0.01859274
p_int:  0.994343666
p_ni:  0.005656327
p_wrong:  7e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.988863522
p_ni:  0.011136476
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
 Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
894 targets
R-HSA-1280218
Reactome
Immune System
2246 targets
R-HSA-168256
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
275 targets
R-HSA-198933
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
894 targets
R-HSA-1280218
Immune System
2246 targets
R-HSA-168256
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
275 targets
R-HSA-198933
Viral Interactions (0)
 No viral interactions found
Disease Associations (null)
 No disease associations found
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alopecia areata
EFO_0004192
2
2
0
1.6
79.7
basal cell carcinoma
EFO_0004193
1
1
0
1.1
5.8
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alopecia areata
EFO_0004192
0
1.6
79.7
basal cell carcinoma
EFO_0004193
0
1.1
5.8
IDG Resources
 No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UL16 binding protein 3
VGNC:3781
472155
Pig
UL16 binding protein 1
445523
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UL16 binding protein 3
Pig
UL16 binding protein 1
Publication Statistics
PubMed Score 20.42
PubMed score by year
PubTator Score 27.63
PubTator score by year
Related Publications
Items per page:
0 of 0
PMID
Year
Title