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Tbio
ULBP1
UL16-binding protein 1

Protein Summary
Description
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229708
  • ENSP00000229708
  • ENSG00000111981

Symbol
  • N2DL1
  • RAET1I
  • N2DL-1
  • RAET1I
  • NKG2DL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.93
tissue sample
0.79
histone modification site profile
0.76
cell type or tissue
0.61
gene perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.96   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.96   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
ULBP3
Tbio
Novelty:  0.0320239
p_int:  0.999999796
p_ni:  3.1e-8
p_wrong:  1.73e-7
Score:  0.938
Data Source:  BioPlex,STRINGDB
GPC3
Tbio
Novelty:  0.00151823
p_int:  0.999739799
p_ni:  0.000260201
Score:  0.189
Data Source:  BioPlex,STRINGDB
TNFSF8
Tbio
Novelty:  0.01292216
p_int:  0.997301992
p_ni:  0.00000236
p_wrong:  0.002695648
Score:  0.307
Data Source:  BioPlex,STRINGDB
IGLL5
Tbio
Novelty:  0.00459259
p_int:  0.964542636
p_ni:  0.030424959
p_wrong:  0.005032406
Score:  0.189
Data Source:  BioPlex,STRINGDB
CPM
Tchem
Family:  Enzyme
Novelty:  0.00520702
p_int:  0.917711865
p_ni:  0.000296915
p_wrong:  0.08199122
Score:  0.345
Data Source:  BioPlex,STRINGDB
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.901102242
p_ni:  2.51e-7
p_wrong:  0.098897507
Score:  0.222
Data Source:  BioPlex,STRINGDB
HCST
Tbio
Novelty:  0.01604587
Score:  0.962
Data Source:  STRINGDB
KLRK1
Tbio
Novelty:  0.0009209
Score:  0.904
Data Source:  STRINGDB
MICA
Tbio
Novelty:  0.03965901
Score:  0.873
Data Source:  STRINGDB
MICB
Tbio
Novelty:  0.00364639
Score:  0.85
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.6
79.7
1
1
0
1.1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
79.7
0
1.1
5.8
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NKG2D ligand 1-like
694341
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NKG2D ligand 1-like
Publication Statistics
PubMed Score 44.96
PubMed score by year
PubTator Score 54.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title