Tbio UHRF2 E3 ubiquitin-protein ligase UHRF2

Protein Summary

Description

E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131. This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q96PU4
• Q5VYR1
• Q5VYR3
• Q659C8
• Q8TAG7

Gene Name

• UHRF2

Ensembl ID

• ENST00000276893
• ENSP00000276893
• ENSG00000147854
• ENST00000468435
• ENSP00000434182

Symbol

• NIRF
• RNF107
• NIRF
• URF2
• RNF107
• TDRD23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
transcription factor binding site profile	0.91
molecular function	0.7
cell type or tissue	0.67
PubMedID	0.67

Protein Classes

PANTHER Classes

Protein / ... / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Uhrf2

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Uhrf2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.43   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 258   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.43   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0