You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UHRF1
E3 ubiquitin-protein ligase UHRF1

Protein Summary
Description
Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612630
  • ENSP00000484739
  • ENSG00000276043
  • ENST00000615884
  • ENSP00000478601
  • ENST00000616255
  • ENSP00000478348
  • ENST00000624301
  • ENSP00000485604

Symbol
  • ICBP90
  • NP95
  • RNF106
  • Np95
  • hNP95
  • ICBP90
  • RNF106
  • TDRD22
  • hUHRF1
  • huNp95
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
interacting protein
0.95
small molecule perturbation
0.9
biological process
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.04   (req: < 5)
Gene RIFs: 126   (req: <= 3)
Antibodies: 361   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.04   (req: >= 5)
Gene RIFs: 126   (req: > 3)
Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0