UGT8
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Protein Summary
Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
- ENST00000310836
- ENSP00000311648
- ENSG00000174607
- ENST00000394511
- ENSP00000378019
- CGT
- UGT4
- CGT
- UGT4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
biological process | 0.76 | ||
microRNA | 0.67 | ||
transcription factor | 0.61 | ||
transcription factor perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 85.39 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 193 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 85.39 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 193 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 21
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (21)
Protein-Protein Interactions (115)
HMOX2
Family: Enzyme
Novelty: 0.00180703
p_int: 0.999771249
p_ni: 0.000228751
Score: 0.225
Data Source: BioPlex,STRINGDB
PTCH1
Novelty: 0.00077635
p_int: 0.991453284
p_ni: 0.008546715
p_wrong: 1e-9
Data Source: BioPlex
HSD11B1
Family: Enzyme
Novelty: 0.00105097
p_int: 0.989522025
p_ni: 0.010477975
Score: 0.274
Data Source: BioPlex,STRINGDB
HMOX1
Family: Enzyme
Novelty: 0.00013981
p_int: 0.988644688
p_ni: 0.011355312
Score: 0.207
Data Source: BioPlex,STRINGDB
ADPGK
Family: Kinase
Novelty: 0.0552414
p_int: 0.983099409
p_ni: 0.016900591
Score: 0.665
Data Source: BioPlex,STRINGDB
NCEH1
Family: Enzyme
Novelty: 0.01528589
p_int: 0.969715196
p_ni: 0.030284804
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (9)
Reactome (4)
KEGG (3)
UniProt (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Glycosphingolipid metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Sphingolipid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Glycosphingolipid metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Sphingolipid metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (3)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glycerophospholipid measurement | 1 | 256 | 256 | 90.1 | |||||
ceramide measurement | 7 | 6 | 8 | 87.3 | |||||
hemoglobin measurement | 4 | 4 | 4 | 77 | |||||
hematocrit | 3 | 2 | 3 | 61.7 | |||||
red blood cell density measurement | 1 | 1 | 1 | 22.3 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glycerophospholipid measurement | 256 | 90.1 | |||||
ceramide measurement | 8 | 87.3 | |||||
hemoglobin measurement | 4 | 77 | |||||
hematocrit | 3 | 61.7 | |||||
red blood cell density measurement | 1 | 22.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | UDP glycosyltransferase 8 | VGNC:715 | 461446 | |||||
Macaque | UDP glycosyltransferase 8 | 702979 | ||||||
Mouse | MGI:109522 | 22239 | ||||||
Rat | RGD:3938 | 50555 | ||||||
Dog | UDP glycosyltransferase 8 | VGNC:48121 | 487910 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | UDP glycosyltransferase 8 | |||||
Macaque | UDP glycosyltransferase 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | UDP glycosyltransferase 8 | |||||
Publication Statistics
PubMed Score 85.39
PubMed score by year
PubTator Score 122.25
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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