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Tbio
UGT8
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

Protein Summary
Description
Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310836
  • ENSP00000311648
  • ENSG00000174607
  • ENST00000394511
  • ENSP00000378019

Symbol
  • CGT
  • UGT4
  • CGT
  • UGT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
biological process
0.76
microRNA
0.67
transcription factor
0.61
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.42   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.42   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
HMOX2
Tchem
Family:  Enzyme
Novelty:  0.00180703
p_int:  0.999771249
p_ni:  0.000228751
Score:  0.225
Data Source:  BioPlex,STRINGDB
PLTP
Tbio
Novelty:  0.00267612
p_int:  0.997317341
p_ni:  0.002682659
Data Source:  BioPlex
SEC22B
Tbio
Novelty:  0.03035448
p_int:  0.993725543
p_ni:  0.006274457
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.991453284
p_ni:  0.008546715
p_wrong:  1e-9
Data Source:  BioPlex
HSD11B1
Tclin
Family:  Enzyme
Novelty:  0.00105097
p_int:  0.989522025
p_ni:  0.010477975
Score:  0.274
Data Source:  BioPlex,STRINGDB
HMOX1
Tchem
Family:  Enzyme
Novelty:  0.00013981
p_int:  0.988644688
p_ni:  0.011355312
Score:  0.207
Data Source:  BioPlex,STRINGDB
RPRM
Tbio
Novelty:  0.02938708
p_int:  0.983784834
p_ni:  0.016215166
Data Source:  BioPlex
ADPGK
Tbio
Family:  Kinase
Novelty:  0.0552414
p_int:  0.983099409
p_ni:  0.016900591
Score:  0.665
Data Source:  BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.980132768
p_ni:  0.019867232
Data Source:  BioPlex
NCEH1
Tchem
Family:  Enzyme
Novelty:  0.01528589
p_int:  0.969715196
p_ni:  0.030284804
Data Source:  BioPlex
Pathways (9)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
3
3
84.3
hematocrit
2
2
2
71.6
red blood cell density measurement
1
1
1
32.7
glomerular filtration rate
2
1
2
12.7
optic disc area measurement
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
84.3
hematocrit
2
71.6
red blood cell density measurement
1
32.7
glomerular filtration rate
2
12.7
optic disc area measurement
1
0.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP glycosyltransferase 8
VGNC:715
461446
Macaque
UDP glycosyltransferase 8
702979
Mouse
MGI:109522
22239
Rat
RGD:3938
50555
Dog
UDP glycosyltransferase 8
VGNC:48121
487910
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP glycosyltransferase 8
Macaque
UDP glycosyltransferase 8
Mouse
Rat
Dog
UDP glycosyltransferase 8
Publication Statistics
PubMed Score 36.42
PubMed score by year
PubTator Score 122.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title