Tbio UGT2B4 UDP-glucuronosyltransferase 2B4

Protein Summary

Description

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

Uniprot Accession IDs

• P06133
• A6NCP7
• B4DT75
• G5E9X8
• O60731
• O60867
• O75614
• P36538
• Q1HBF9
• Q6QQX7
• UDPGT 2B4

Gene Name

• UGT2B4

Ensembl ID

• ENST00000305107
• ENSP00000305221
• ENSG00000156096
• ENST00000512583
• ENSP00000421290

Symbol

• UGT2B11
• HLUG25
• UDPGTH1
• UGT2B11
• UDPGT2B4
• UDPGTh-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.76
molecular function	0.63
pathway	0.61
cell line	0.53
cellular component	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.66   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.66   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0