UGT1A6
UDP-glucuronosyltransferase 1-6
Protein Summary
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme enc ...more
- ENST00000305139
- ENSP00000303174
- ENSG00000167165
- ENST00000373424
- ENSP00000362523
- GNT1
- UGT1
- GNT1
- UGT1
- HLUGP
- UDPGT
- UGT1A
- UGT1C
- UGT1E
- UGT1F
- HLUGP1
- UGT-1A
- UGT-1C
- UGT-1E
- UGT1.1
- UGT1.3
- UGT1.5
- UGT1A1
- UGT1A3
- UGT1A5
- UGT1-01
- UGT1-03
- UGT1-05
- UGT1A6S
- hUG-BR1
- UDPGT 1-6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.88 | ||
chemical | 0.88 | ||
trait | 0.86 | ||
molecular function | 0.79 | ||
disease | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 784.93 (req: < 5)
Gene RIFs: 61 (req: <= 3)
Antibodies: 112 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 784.93 (req: >= 5)
Gene RIFs: 61 (req: > 3)
Antibodies: 112 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (149)
Nearest Tclin Targets (17)
Upstream (9)
Downstream (8)
1 – 5 of 9
Pathways (24)
Reactome (4)
KEGG (10)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Glucuronidation | ||||
Reactome | Metabolism | ||||
Reactome | Phase II - Conjugation of compounds | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Glucuronidation | ||||
Metabolism | ||||
Phase II - Conjugation of compounds | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (5)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
bilirubin measurement | 16 | 74 | 136 | 100 | |||||
vitamin D measurement | 4 | 5 | 5 | 96.7 | |||||
blood metabolite measurement | 1 | 2 | 8 | 95.6 | |||||
testosterone measurement | 7 | 4 | 7 | 92.6 | |||||
serum metabolite measurement | 2 | 2 | 10 | 92.6 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
bilirubin measurement | 136 | 100 | |||||
vitamin D measurement | 5 | 96.7 | |||||
blood metabolite measurement | 8 | 95.6 | |||||
testosterone measurement | 7 | 92.6 | |||||
serum metabolite measurement | 10 | 92.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:3580629 | 394435 | ||||||
Dog | UDP glucuronosyltransferase 1 family, polypeptide A6 | 403629 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Dog | UDP glucuronosyltransferase 1 family, polypeptide A6 | |||||
Publication Statistics
PubMed Score 784.93
PubMed score by year
PubTator Score 155.79
PubTator score by year
Related Publications
Text Mined References (118)
GeneRif Annotations (61)
Items per page:
0 of 0
PMID | Year | Title |
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