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Tbio
UGT1A4
UDP-glucuronosyltransferase 1-4

Protein Summary
Description
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encod ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373409
  • ENSP00000362508
  • ENSG00000244474
  • ENST00000450233
  • ENSP00000408608

Symbol
  • GNT1
  • UGT1
  • GNT1
  • UGT1
  • UDPGT
  • UGT1A
  • UGT1D
  • UGT-1A
  • UGT-1D
  • UGT1.1
  • UGT1.4
  • UGT1A1
  • HUG-BR2
  • UGT1-01
  • UGT1-04
  • UGT1A4S
  • hUG-BR1
  • UDPGT 1-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
molecular function
0.79
trait
0.75
chemical
0.72
cellular component
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.61   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.61   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0