Tclin UGCG Ceramide glucosyltransferase

Protein Summary

Description

Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase". This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• Q16739
• Q5T258

Gene Name

• UGCG

Ensembl ID

• ENST00000374279
• ENSP00000363397
• ENSG00000148154

Symbol

• GCS
• GLCT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
transcription factor binding site profile	0.8
small molecule perturbation	0.75
PubMedID	0.73
cell type or tissue	0.69

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Ceramide Glucosyltransferase

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Ceramide Glucosyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.05   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 171   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.05   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 109

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2