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Tbio
UFSP2
Ufm1-specific protease 2

Protein Summary
Description
Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation. This gene encodes a highly conserved cysteine protease. The protein cleaves two C-terminal residues from ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein. Activation of ubiquitin-fold modifier 1 by the encoded protein exposes a C-terminal glycine residue that allows interaction with other proteins and transfer to its target protein. An allelic variant of this gene has been associated with Beukes hip dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264689
  • ENSP00000264689
  • ENSG00000109775

Symbol
  • C4orf20
  • BHD
  • SEMDDR
  • C4orf20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.83
histone modification site profile
0.81
virus perturbation
0.76
transcription factor binding site profile
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.65   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.65   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
TIGIT
Tbio
Novelty:  0.0064542
p_int:  0.99634528
p_ni:  0.00365472
Data Source:  BioPlex
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.981056474
p_ni:  0.018943525
Data Source:  BioPlex
CDHR5
Tbio
Novelty:  0.08525208
p_int:  0.98062402
p_ni:  0.01937598
Data Source:  BioPlex
P10321
Tbio
Novelty:  0.00698601
p_int:  0.975514931
p_ni:  0.024485069
Data Source:  BioPlex
RAB33B
Tbio
Family:  Enzyme
Novelty:  0.06381712
p_int:  0.972959416
p_ni:  0.027040584
Data Source:  BioPlex
ASIC1
Tchem
Family:  IC
Novelty:  0.00705323
p_int:  0.969007395
p_ni:  0.030992605
Score:  0.173
Data Source:  BioPlex,STRINGDB
PODXL2
Tbio
Novelty:  0.09100487
p_int:  0.964213799
p_ni:  0.035786201
Data Source:  BioPlex
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
p_int:  0.953582276
p_ni:  0.046417724
Data Source:  BioPlex
AMIGO3
Tdark
Novelty:  7.6744186
p_int:  0.952669845
p_ni:  0.047330155
Data Source:  BioPlex
CD79A
Tbio
Novelty:  0.00118942
p_int:  0.947974162
p_ni:  0.052025838
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.5
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
15.8
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
UFM1 specific peptidase 2
699794
Mouse
MGI:1913679
192169
Rat
RGD:1311161
361151
Dog
UFM1 specific peptidase 2
VGNC:51837
482908
Horse
UFM1 specific peptidase 2
100057294
Species
Name
OMA
EggNOG
Inparanoid
Macaque
UFM1 specific peptidase 2
Mouse
Rat
Dog
UFM1 specific peptidase 2
Horse
UFM1 specific peptidase 2
Publication Statistics
PubMed Score 7.65
PubMed score by year
PubTator Score 3.58
PubTator score by year
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Related Publications
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PMID
Year
Title