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Tbio
UFL1
E3 UFM1-protein ligase 1

Protein Summary
Description
E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369278
  • ENSP00000358283
  • ENSG00000014123

Symbol
  • KIAA0776
  • NLBP
  • RCAD
  • NLBP
  • RCAD
  • Maxer
  • KIAA0776
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
interacting protein
0.85
kinase perturbation
0.84
cell type or tissue
0.75
tissue
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.03   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.03   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (282)
DDRGK1
Tbio
Novelty:  0.10774064
p_int:  0.999999081
p_ni:  9.19e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
CDK5RAP3
Tbio
Novelty:  0.03628071
p_int:  0.999984423
p_ni:  0.000015418
p_wrong:  1.59e-7
Score:  0.991
Data Source:  BioPlex,STRINGDB
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.998921667
p_ni:  0.001078333
Score:  0.216
Data Source:  BioPlex,STRINGDB
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.927273215
p_ni:  0.072726766
p_wrong:  1.9e-8
Data Source:  BioPlex
MRVI1
Tbio
Novelty:  0.02987514
p_int:  0.862782389
p_ni:  0.137217611
Data Source:  BioPlex
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
p_int:  0.859744991
p_ni:  0.140255009
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.840238215
p_ni:  0.159761778
p_wrong:  8e-9
Data Source:  BioPlex
TNF
Tclin
Novelty:  0.00001457
p_int:  0.771261693
p_ni:  0.228738176
p_wrong:  1.31e-7
Score:  0.179
Data Source:  BioPlex,STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.760666519
p_ni:  0.239333477
p_wrong:  4e-9
Data Source:  BioPlex
UBA5
Tbio
Novelty:  0.05089296
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
91.9
body height
1
1
1
81
Headache
1
1
1
80.2
2
2
0
1.2
67.5
1
1
0
1.1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
91.9
body height
1
81
Headache
1
80.2
0
1.2
67.5
0
1.1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UFM1 specific ligase 1
VGNC:8572
462889
Macaque
UFM1 specific ligase 1
704454
Mouse
MGI:1914740
67490
Rat
RGD:1309308
313115
Dog
UFM1 specific ligase 1
VGNC:48115
474999
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UFM1 specific ligase 1
Macaque
UFM1 specific ligase 1
Mouse
Rat
Dog
UFM1 specific ligase 1
Publication Statistics
PubMed Score 37.03
PubMed score by year
PubTator Score 16.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title