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Tbio
UCP2
Mitochondrial uncoupling protein 2

Protein Summary
Description
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310473
  • ENSP00000312029
  • ENSG00000175567

Symbol
  • SLC25A8
  • UCPH
  • BMIQ4
  • SLC25A8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
biological process
0.92
kinase perturbation
0.91
transcription factor perturbation
0.88
transcription factor binding site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1358.53   (req: < 5)
Gene RIFs: 252   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1358.53   (req: >= 5)
Gene RIFs: 252   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (169)
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.999661757
p_ni:  0.000338243
Data Source:  BioPlex
MUC7
Tbio
Novelty:  0.00750654
p_int:  0.999484948
p_ni:  0.000047632
p_wrong:  0.00046742
Score:  0.205
Data Source:  BioPlex,STRINGDB
CST2
Tbio
Novelty:  0.02114441
p_int:  0.999113971
p_ni:  0.000886028
p_wrong:  2e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
IGHA2
Tbio
p_int:  0.997892461
p_ni:  0.002107519
p_wrong:  2e-8
Data Source:  BioPlex
CST4
Tbio
Novelty:  0.00773554
p_int:  0.980175778
p_ni:  0.019823077
p_wrong:  0.000001145
Data Source:  BioPlex
CRNN
Tbio
Novelty:  0.01648731
p_int:  0.977711382
p_ni:  0.022288384
p_wrong:  2.34e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
ZG16B
Tbio
Novelty:  0.08792924
p_int:  0.957969221
p_ni:  0.042030779
Data Source:  BioPlex
PIGR
Tbio
Novelty:  0.0025812
p_int:  0.936661211
p_ni:  0.020607926
p_wrong:  0.042730863
Score:  0.183
Data Source:  BioPlex,STRINGDB
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.929859461
p_ni:  0.070140539
Data Source:  BioPlex
SERPINB3
Tbio
Novelty:  0.00325244
p_int:  0.854048836
p_ni:  0.145951164
Score:  0.256
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Mitochondrial Uncoupling Proteins
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Reactome
The fatty acid cycling model
Name
Explore in Pharos
Explore in Source
Metabolism
Mitochondrial Uncoupling Proteins
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
The fatty acid cycling model
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
10.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
10.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uncoupling protein 2
VGNC:10233
451416
Macaque
uncoupling protein 2
574198
Mouse
MGI:109354
22228
Rat
RGD:3932
54315
Dog
uncoupling protein 2
VGNC:48111
403576
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uncoupling protein 2
Macaque
uncoupling protein 2
Mouse
Rat
Dog
uncoupling protein 2
Publication Statistics
PubMed Score 1358.53
PubMed score by year
PubTator Score 662.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title