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Tbio
UCP1
Mitochondrial brown fat uncoupling protein 1

Protein Summary
Description
Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity). Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP syn ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262999
  • ENSP00000262999
  • ENSG00000109424

Symbol
  • SLC25A7
  • UCP
  • UCP
  • SLC25A7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
cellular component
0.72
disease
0.7
histone modification site profile
0.68
chemical
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2294.07   (req: < 5)
Gene RIFs: 105   (req: <= 3)
Antibodies: 399   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2294.07   (req: >= 5)
Gene RIFs: 105   (req: > 3)
Antibodies: 399   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
NME2P1
Tdark
Family:  Kinase
p_int:  0.987141634
p_ni:  0.012858343
p_wrong:  2.3e-8
Data Source:  BioPlex
CIDEA
Tbio
Novelty:  0.00901749
Score:  0.925
Data Source:  STRINGDB
PRDM16
Tbio
Family:  TF; Epigenetic
Novelty:  0.00261891
Score:  0.92
Data Source:  STRINGDB
FNDC5
Tbio
Novelty:  0.0015827
Score:  0.916
Data Source:  STRINGDB
SLC25A14
Tbio
Family:  Transporter
Novelty:  0.02268116
Score:  0.913
Data Source:  STRINGDB
SLC25A27
Tbio
Family:  Transporter
Novelty:  0.01910376
Score:  0.911
Data Source:  STRINGDB
UCP3
Tbio
Novelty:  0.00155156
Score:  0.905
Data Source:  STRINGDB
UCP2
Tbio
Novelty:  0.00083843
Score:  0.904
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.902
Data Source:  STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.883
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (64)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Mitochondrial Uncoupling Proteins
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Reactome
The fatty acid cycling model
Name
Explore in Pharos
Explore in Source
Metabolism
Mitochondrial Uncoupling Proteins
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
The fatty acid cycling model
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at onset
1
1
0
5.9
9.3
Alzheimer disease
1
1
0
5.9
9.3
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at onset
0
5.9
9.3
Alzheimer disease
0
5.9
9.3
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uncoupling protein 1
VGNC:10385
461504
Macaque
uncoupling protein 1
574124
Mouse
MGI:98894
22227
Rat
RGD:3931
24860
Dog
uncoupling protein 1 [Source:HGNC Symbol;Acc:HGNC:12517]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uncoupling protein 1
Macaque
uncoupling protein 1
Mouse
Rat
Dog
uncoupling protein 1 [Source:HGNC Symbol;Acc:HGNC:12517]
Publication Statistics
PubMed Score 2294.07
PubMed score by year
PubTator Score 859.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title