Tbio UCN2 Urocortin-2

Protein Summary

Description

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96RP3
• Q9BUG0

Gene Name

• UCN2

Ensembl ID

• ENST00000273610
• ENSP00000273610
• ENSG00000145040

Symbol

• SRP
• URP
• UR
• SRP
• URP
• UCNI
• UCN-II

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.87
cell type or tissue	0.82
gene perturbation	0.62
tissue	0.55
biological term	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.38   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.38   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0