You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UCKL1
Uridine-cytidine kinase-like 1

Protein Summary
Description
May contribute to UTP accumulation needed for blast transformation and proliferation. The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354216
  • ENSP00000346155
  • ENSG00000198276
  • ENST00000358711
  • ENSP00000351546
  • ENST00000369908
  • ENSP00000358924

Symbol
  • URKL1
  • UCK1L
  • URKL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
cell type or tissue
0.76
protein domain
0.73
transcription factor binding site profile
0.71
transcription factor
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.49   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.49   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
UPRT
Tbio
Family:  Enzyme
Novelty:  0.00506163
p_int:  0.999999408
p_ni:  5.92e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
UCK2
Tbio
Family:  Kinase
Novelty:  0.02417595
p_int:  0.99998485
p_ni:  0.000015149
p_wrong:  1e-9
Score:  0.975
Data Source:  BioPlex,STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
p_int:  0.999598486
p_ni:  0.000401514
Score:  0.631
Data Source:  BioPlex,STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.998767496
p_ni:  0.001232504
Data Source:  BioPlex
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.994222154
p_ni:  0.005777845
p_wrong:  1e-9
Data Source:  BioPlex
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
p_int:  0.978733707
p_ni:  0.021266293
Score:  0.232
Data Source:  BioPlex,STRINGDB
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.957109058
p_ni:  0.042890942
Data Source:  BioPlex
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.950654042
p_ni:  0.049345958
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.874109902
p_ni:  0.125890098
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.830043568
p_ni:  0.169956432
Data Source:  BioPlex
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 4 of 4
TYMS
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (12)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Pyrimidine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Pyrimidine salvage
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
3
88
mean reticulocyte volume
1
1
1
79
alkaline phosphatase measurement
2
3
2
6.2
75.5
mean corpuscular volume
1
1
1
59
reticulocyte measurement
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
88
mean reticulocyte volume
1
79
alkaline phosphatase measurement
2
6.2
75.5
mean corpuscular volume
1
59
reticulocyte measurement
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uridine-cytidine kinase 1 like 1
VGNC:10023
458424
Macaque
uridine-cytidine kinase 1 like 1
694692
Mouse
MGI:1915806
68556
Rat
RGD:1565465
499956
Dog
uridine-cytidine kinase 1 like 1
VGNC:48106
612562
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uridine-cytidine kinase 1 like 1
Macaque
uridine-cytidine kinase 1 like 1
Mouse
Rat
Dog
uridine-cytidine kinase 1 like 1
Publication Statistics
PubMed Score 6.49
PubMed score by year
PubTator Score 2.95
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title