Tbio UBXN7 UBX domain-containing protein 7

Protein Summary

Description

Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.

Uniprot Accession IDs

• O94888
• D3DXB3
• Q6ZP77
• Q86X20
• Q8N327

Gene Name

• UBXN7

Ensembl ID

• ENST00000296328
• ENSP00000296328
• ENSG00000163960

Symbol

• KIAA0794
• UBXD7
• UBXD7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.87
protein domain	0.85
histone modification site profile	0.83
virus perturbation	0.72
microRNA	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.91   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 27   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.91   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0